Journal ArticleDOI
Role of angiogenesis in tumor growth and metastasis
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TLDR
Preclinical studies have shown that endostatin effectively inhibits tumor growth and shrinks existing tumor blood vessels and therapy with endogenous inhibitors of angiogenesis, such asendostatin and angiostatin may reverse the angiogenic switch preventing growth of tumor vasculature.About:
This article is published in Seminars in Oncology.The article was published on 2002-12-16. It has received 2641 citations till now. The article focuses on the topics: Angiogenic Switch & Endostatin.read more
Citations
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Cancer genes and the pathways they control.
TL;DR: The purposes of this review are to highlight examples of progress in many areas of cancer research, indicate where knowledge is scarce and point out fertile grounds for future investigation.
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Microenvironmental regulation of metastasis
TL;DR: Experimental data demonstrating the role of the microenvironment in metastasis is described, areas for future research are identified and possible new therapeutic avenues are suggested.
Journal ArticleDOI
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan,Rebecca D. Riba,Stergios Zacharoulis,Anna H. Bramley,Loic Vincent,Carla Costa,Daniel D. MacDonald,David K. Jin,Koji Shido,Scott A. Kerns,Zhenping Zhu,Daniel J. Hicklin,Yan Wu,Jeffrey L. Port,Nasser K. Altorki,Elisa Port,Davide Ruggero,Sergey V. Shmelkov,Kristian K. Jensen,Shahin Rafii,David Lyden +20 more
TL;DR: A requirement for VEGFR1+ haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) home to tumour-specific pre-metastatic sites and form cellular clusters before the arrival of tumour cells is demonstrated.
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The molecular biology of head and neck cancer
TL;DR: The recent literature on tumour heterogeneity, field cancerization, molecular pathogenesis and the underlying causative cancer genes that can be exploited for novel and personalized treatments of patients with HNSCC are discussed.
References
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Book
Harrison's Principles of Internal Medicine
TL;DR: In this article, Cardinal Manifestations of Disease Genetics and Disease Clinical Pharmacology Nutrition Infectious Disease Disorders Of The Cardiovascular System Disorders Of the Kidney And Urinary Tract Disorders Of Gastrointestinal System Disorders of The Immune System, Connective Tissue And Joints Hematology And Oncology Endocrinology And Metabolism Neurologic Disorders Environmental And Occupational Hazards.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
Michael S. O'Reilly,Thomas Boehm,Yuen Shing,Naomi Fukai,George Vasios,William S. Lane,Evelyn Flynn,James R Birkhead,Bjorn R. Olsen,Judah Folkman +9 more
TL;DR: This work has identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma, a 20 kDa C-terminal fragment of collagen XVIII that specifically inhibits endothelial proliferation and potently inhibitsAngiogenesis and tumor growth.
Journal ArticleDOI
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma
Michael S. O'Reilly,Michael S. O'Reilly,Lars Holmgren,Lars Holmgren,Yuen Shing,Yuen Shing,Catherine Chen,Catherine Chen,Rosalind A. Rosenthal,Rosalind A. Rosenthal,Marsha A. Moses,Marsha A. Moses,William S. Lane,Yihai Cao,E. Helene Sage,Judah Folkman +15 more
TL;DR: It is shown that the inhibition of metastases by a primary mouse tumor is mediated, at least in part, by angiostatin, and a corresponding fragment of human plasminogen has similar activity.
Journal ArticleDOI
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Gabriele Bergers,Rolf A. Brekken,Gerald McMahon,Thiennu H. Vu,Takeshi Itoh,Kazuhiko Tamaki,Kazuhiko Tanzawa,Philip E. Thorpe,Shigeyoshi Itohara,Zena Werb,Douglas Hanahan +10 more
TL;DR: The results show that MMP-9 is a component of theAngiogenic switch, and MMP inhibitors reduce angiogenic switching, and tumour number and growth, as does genetic ablation of M MP-9.