Journal ArticleDOI
Roles of interleukin 1 beta and tumor necrosis factor in lipopolysaccharide fever in rats
TLDR
The hypotheses that IL-1 beta is responsible for a significant part of LPS fever and that TNF acts as an endogenous antipyretic to limit the magnitude of L PS fever in the rat are supported.Abstract:
The roles of interleukin 1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF) in lipopolysaccharide (LPS)-induced fever were investigated in the rat. We used antisera against IL-1 beta and TNF to determine whether we could alter the fever by blocking the action of these cytokines. The intravenous injection of antiserum IL-1 beta 3.5 days before the intraperitoneal injection of LPS resulted in a mean fever that was significantly lower than that seen in rats that had been injected with control serum (0.36 +/- 0.11 vs. 0.82 +/- 0.16 degrees C, P = 0.016). The intravenous injection of antiserum against TNF 3.5 days before the intraperitoneal injection of LPS did not block the fever but significantly enhanced it (1.31 +/- 0.16 vs. 0.82 +/- 0.16 degrees C, P = 0.027). These data support the hypotheses that IL-1 beta is responsible for a significant part of LPS fever and that TNF acts as an endogenous antipyretic to limit the magnitude of LPS fever in the rat.read more
Citations
More filters
Journal ArticleDOI
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TL;DR: Findings are reviewed that have documented which cytokines have been shown to influence hormone secretion from the HPA axis, determined under what physiological/pathophysiological circumstances endogenous cytokines regulate HPAaxis activity, established the possible sites of cytokine action on HPA Axis hormone secretion, and identified the potential neuroanatomic and pharmacological mechanisms by which cytokine signal the neuroendocrine hypothalamus.
Journal ArticleDOI
Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion
Reiko Horai,Masahide Asano,Katsuko Sudo,Hirotaka Kanuka,Masatoshi Suzuki,Masugi Nishihara,Michio Takahashi,Yoichiro Iwakura +7 more
TL;DR: IL-1β but not IL-1α is crucial in febrile and neuro-immuno-endocrine responses, and that this is because IL- 1α expression in the brain is dependent on IL-2β, as well as in peritoneal macrophages stimulated with lipopolysaccharide in vitro.
Journal ArticleDOI
Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication☆
Linda R. Watkins,Lisa E. Goehler,Jane Relton,Nicole Tartaglia,Lee H. Silbert,David P. Martin,Steven F. Maier +6 more
TL;DR: It is demonstrated that subdiaphragmatic vagal transection disrupts the hyperthermia-inducing effects of recombinant human IL-1 beta and stress, providing evidence for a novel route of immune-brain communication, as well as a novel routes whereby stress can influence physiological processes.
Journal ArticleDOI
Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice
Hui Zheng,Daniel S. Fletcher,Wieslaw Kozak,Minghao Jiang,Kathryn J. Hofmann,Carole A. Corn,Darlusz Soszynski,Christina Grabiec,Myrna E. Trumbauer,Alan Shaw,Matthew J. Kostura,Karla Stevens,Hugh Rosen,Robert J. North,Howard Y. Chen,Michael J. Tocci,Matthew J. Kluger,Lex H.T. Van der Ploeg +17 more
TL;DR: A central role for IL-1 beta as a pyrogen and a mediator of the acute-phase response in a subset of inflammatory disease models is highlighted, and the notion that blocking the action of a single key cytokine can alter the course of specific immune and inflammatory responses is supported.
Journal ArticleDOI
Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia.
E. Fischer,M. A. Marano,K J Van Zee,C S Rock,A S Hawes,W A Thompson,Laura E. DeForge,J S Kenney,Daniel G. Remick,D C Bloedow +9 more
TL;DR: It is concluded that an exaggerated systemic IL-1 beta response is characteristic of lethal E. coli septic shock, and contributes significantly to the hemodynamic and metabolic consequences of E. Escherichia coli sepsis.