ROS-dependent HMGB1 secretion upregulates IL-8 in upper airway epithelial cells under hypoxic condition.
TLDR
It is suggested thatHMGB1 is secreted in hypoxic condition via ROS-dependent mechanism and secreted HMGB1 participates in IL-8 upregulation mediating inflammatory response.About:
This article is published in Mucosal Immunology.The article was published on 2017-05-01 and is currently open access. It has received 31 citations till now. The article focuses on the topics: Nasal Lavage Fluid & Mucous membrane of nose.read more
Citations
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Cancer-cell-secreted CXCL11 promoted CD8 + T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC
Qun Gao,Shumin Wang,Xinfeng Chen,Shaoyan Cheng,Zhen Zhang,Feng Li,Lan Huang,Yang Yang,Bin Zhou,Dongli Yue,Dan Wang,Ling Cao,Nomathamsanqa Resegofetse Maimela,Bin Zhang,Jane J. Yu,Liping Wang,Yi Zhang +16 more
TL;DR: It is demonstrated that DOC induces CD8+ T cell recruitment to the tumor microenvironment by enhancing the secretion of HMGB1 and CXCL11, thus improving the anti-tumor efficacy, indicating that modulating the HMGB 1-CXCL 11 axis might be helpful for NSCLC treatment.
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The mechanism of HMGB1 secretion and release
TL;DR: In this article , the authors introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of its secretion and release, which may help develop new HMGB-targeted drugs for various conditions, especially inflammatory diseases and tissue damage.
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sRAGE attenuates angiotensin II-induced cardiomyocyte hypertrophy by inhibiting RAGE-NFκB-NLRP3 activation.
TL;DR: It is concluded that RAGE induces cardiac hypertrophy through the activation of the PKCs-ERK1/2 and NF-κB-NLRP3-IL1β signaling pathway, and it is suggested that Rage-NL RP3 may be an important mediator of Ang II-induced cardiomyocytehypertrophy.
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Cigarette smoke promotes COPD by activating platelet-activating factor receptor and inducing neutrophil autophagic death in mice.
TL;DR: It is reported that CS induction of autophagy in neutrophils by activating platelet- activating factor receptor (PAFR) promotes COPD progression in mouse, and inhibition of PAFR may provide potential therapeutic benefits in the treatment of patients with COPD.
References
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
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High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal.
Michael T. Lotze,Kevin J. Tracey +1 more
TL;DR: These features of HMGB1 are discussed and recent advances that have led to the preclinical development of therapeutics that modulateHMGB1 release and activity are summarized.
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Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein.
Jong Sung Park,Daiva Svetkauskaite,Qianbin He,Jae-Yeol Kim,Derek Strassheim,Akitoshi Ishizaka,Edward Abraham +6 more
TL;DR: Interactions ofHMGB1 with TLR 2 and TLR 4 may provide an explanation for the ability of HMGB1 to generate inflammatory responses that are similar to those initiated by LPS.
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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Tiziana Bonaldi,Fabio Talamo,Paola Scaffidi,Denise Ferrera,Annalisa Porto,Angela Bachi,Anna Rubartelli,Alessandra Agresti,Marco Bianchi +8 more
TL;DR: It is shown here that in all cells HMGB1 shuttles actively between the nucleus and cytoplasm, and secreted when monocytic cells receive an appropriate second signal.
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The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin MEDIATION OF NEURITE OUTGROWTH AND CO-EXPRESSION OF RAGE AND AMPHOTERIN IN THE DEVELOPING NERVOUS SYSTEM
Osamu Hori,Jerold Brett,Timothy Slattery,Rong Cao,Jinghua Zhang,Jing Xian Chen,Mariko Nagashima,Erik R. Lundh,Sharmila Vijay,Di Nitecki,John Morser,David M. Stern,Ann Marie Schmidt +12 more
TL;DR: The receptor for advanced glycation end products (RAGE), a newly-identified member of the immunoglobulin superfamily, mediates interactions of AGE-modified proteins with endothelium and other cell types.
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LPS may enhance expression and release of HMGB1 in human nasal epithelial cells in vitro Espressione e rilascio della proteina HMGB1 da coltura di cellule epiteliali nasali dopo stimolazione con LPS
D. Chen,L. M. BeLLussi,L. Chen +2 more