Journal ArticleDOI
Roundup® confers cytotoxicity through DNA damage and Mitochondria-Associated apoptosis induction
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TLDR
It is demonstrated that RDP can induce A549 cells cytotoxic effects in vitro at the concentration lower than the occupational exposures level of workers, which means RDP has a potential threat to human health.About:
This article is published in Environmental Pollution.The article was published on 2019-09-01. It has received 27 citations till now. The article focuses on the topics: DNA damage & Apoptosis.read more
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Journal ArticleDOI
Effects of glyphosate exposure on human health: Insights from epidemiological and in vitro studies
Lidiane Pignaton Agostini,Raquel Spinassé Dettogni,Raquel Silva dos Reis,Elaine Stur,Eldamária de Vargas Wolfgramm dos Santos,Diego do Prado Ventorim,Fernanda Mariano Garcia,Rodolfo C. Cardoso,Jones Bernardes Graceli,Iúri Drumond Louro +9 more
TL;DR: Based on currently available in vitro and epidemiological data, it is not possible to confirm the complete safety of GLY use, which will require additional comprehensive studies in animal models and humans.
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Reactive oxygen species-evoked endoplasmic reticulum stress mediates 1-nitropyrene-induced epithelial-mesenchymal transition and pulmonary fibrosis.
Lin Fu,Hui Zhao,Ying Xiang,Hui-Xian Xiang,Biao Hu,Zhu-Xia Tan,Xue Lu,Lan Gao,Bo Wang,Hua Wang,Cheng Zhang,De-Xiang Xu +11 more
TL;DR: In this article, the authors investigated whether chronic 1-nitropyrene exposure induces pulmonary fibrosis and showed that cell migration and invasion were accelerated in 1-NP-exposed pulmonary epithelial cells, while reactive oxygen species (ROS) were increased and endoplasmic reticulum (ER) stress was activated.
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Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology
Xiaojing Wang,Qi Lu,Jingchao Guo,Irma Ares,Marta Martínez,María-Rosa Martínez-Larrañaga,Xu Wang,Arturo Anadón,María-Aránzazu Martínez +8 more
TL;DR: This review provides a comprehensive introduction to the toxicity of GLYP and systematically summarizes the toxicity mechanism from the perspective of oxidative stress, including GLYP-mediated oxidative damage, changes in antioxidant status, altered signaling pathways, and the regulation of oxidative Stress by exogenous substances.
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Adjuvant contributes Roundup's unexpected effects on A549 cells
TL;DR: It is concluded that the RDP's effect of apoptosis and DNA damage on human A549 cells is related to the presence of adjuvant POEA in formulation, independent of the herbicidal active ingredient GP.
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Roundup-Induced AMPK/mTOR-Mediated Autophagy in Human A549 Cells.
TL;DR: Experimental results showed that RDP has the ability to induce AMPK/mTOR-mediated cell autophagy in human A549 cells and the effects induced by RDP were related to its adjuvant polyethoxylated tallow amine (POEA), not its herbicidal active ingredient glyphosate isopropylamine salt (GP).
References
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The BCL-2 protein family: opposing activities that mediate cell death
TL;DR: New insights into interactions among BCL-2 family proteins reveal how these proteins are regulated, but a unifying hypothesis for the mechanisms they use to activate caspases remains elusive.
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Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
TL;DR: The results indicate that activation of CAD downstream of the caspase cascade is responsible for internucleosomal DNA degradation during apoptosis, and that ICAD works as an inhibitor of this process.
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Trends in glyphosate herbicide use in the United States and globally
TL;DR: Glyphosate will likely remain the most widely applied pesticide worldwide for years to come, and interest will grow in quantifying ecological and human health impacts, according to published global pesticide use data.
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An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis CYTOCHROME c-INDEPENDENT ACTIVATION OF CASPASE-9 BY CASPASE-12
TL;DR: Li et al. as mentioned in this paper showed that recombinant caspase-12 specifically cleaves and activates procaspase 9 in cytosolic extracts, which catalyzes cleavage of -3, which is inhibited by a specific inhibitor.
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Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines.
Céline Gasnier,Coralie Dumont,Nora Benachour,Emilie Clair,Marie-Christine Chagnon,Gilles-Eric Séralini +5 more
TL;DR: A real cell impact of glyphosate-based herbicides residues in food, feed or in the environment has thus to be considered, and their classifications as carcinogens/mutagens/reprotoxics is discussed.