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Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.

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TLDR
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis, so representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition.
Abstract
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis. In July 2005, the National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network convened a second meeting on anaphylaxis, which included representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition of anaphylaxis, establish clinical criteria that would accurately identify cases of anaphylaxis with high precision, further review the evidence on the most appropriate management of anaphylaxis, and outline the research needs in this area.

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Citations
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Hymenoptera venom immunotherapy.

TL;DR: Advances in subcutaneous venom immunotherapy are examined, which include the immunological mechanisms of early and long-term efficacy, indications and contraindications, selection of venom, treatment protocols, duration, risk factors for systemic reactions in untreated and treated patients as well as for relapse following cessation of treatment.
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SAFE: a multidisciplinary approach to anaphylaxis education in the emergency department

TL;DR: The SAFE system is designed as a tool to raise awareness of anaphylaxis and its treatments among individuals at risk and the ED personnel charged with their care and future studies need to examine the impact of the SAFe system in decreasing the morbidity and mortality rates associated with anphylaxis.
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Childhood Food Allergies: Current Diagnosis, Treatment, and Management Strategies

TL;DR: The purpose of this review is to aid clinicians in translating the NIAID guidelines into primary care practice and includes the following content domains: the definition and mechanism of Childhood food allergy, differences between food allergy and food intolerance, the epidemiology of childhood food allergy in the United States, and future directions in food allergy research and practice.
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Adverse allergic reactions to linear ionic gadolinium-based contrast agents: experience with 194, 400 injections.

TL;DR: The authors' experience with the administration of four gadolinium-based contrast agents (GBCA; gadopentetate dimeglumine, gadofosveset trisodium, gadoxetate disodium and gadobenate dime glumine) in a large study population at a single, large academic medical centre is reported.
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The effect of provision of an adrenaline autoinjector on quality of life in children with food allergy.

TL;DR: It is shown that epinephrine is rapidly absorbed in the first 20 to 30 minutes after administration through either the sublingual or intramuscular route, potentially suitable for phase I studies in human subjects and might eventually be useful for the first-aid treatment of anaphylaxis in community settings.
References
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Journal ArticleDOI

Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents

TL;DR: Six children and adolescents who died of anaphylactic reactions to foods and seven others who nearly died and required intubation were identified and the failure to recognize the severity of these reactions and to administer epinephrine promptly increases the risk of a fatal outcome.
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Fatalities due to anaphylactic reactions to foods.

TL;DR: Fatal anaphylactic reactions to foods are continuing to occur, and better characterization might lead to better prevention, and peanuts and tree nuts accounted for more than 90% of the fatalities.
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Clinical features and severity grading of anaphylaxis

TL;DR: A simple grading system and definition of anaphylaxis has potential value for defining reaction severity in clinical practice and research settings and appears to be the major determinants of reaction severity.
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Advances in H1-Antihistamines

TL;DR: There are clinically relevant differences among H1-antihistamines in their pharmacology and safety profiles in allergic rhinoconjunctivitis and chronic urticaria.
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