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Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.

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TLDR
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis, so representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition.
Abstract
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis. In July 2005, the National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network convened a second meeting on anaphylaxis, which included representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition of anaphylaxis, establish clinical criteria that would accurately identify cases of anaphylaxis with high precision, further review the evidence on the most appropriate management of anaphylaxis, and outline the research needs in this area.

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Citations
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Mas-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs.

TL;DR: The recent elucidation of cryogenic electron microscopy structures of MRGPRX2 and -4 is expected to facilitate and advance drug development for these receptors, which have great potential as future drug targets.
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Managing side effects of the novel taxane cabazitaxel in castrate-resistant prostate cancer.

TL;DR: The vital role of nurses in identifying patients at high risk for AEs associated with cabazitaxel therapy is reviewed and strategies for prevention and management of symptoms are reviewed.
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Incidence of anaphylaxis and accidental peanut exposure: A systematic review.

TL;DR: In this article, a systematic literature review and meta-analysis was conducted to determine the incidence of peanut-induced anaphylaxis in children and/or adolescents with PA, where the authors used the I2 statistic as the measure of heterogeneity.
References
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Journal ArticleDOI

Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents

TL;DR: Six children and adolescents who died of anaphylactic reactions to foods and seven others who nearly died and required intubation were identified and the failure to recognize the severity of these reactions and to administer epinephrine promptly increases the risk of a fatal outcome.
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Fatalities due to anaphylactic reactions to foods.

TL;DR: Fatal anaphylactic reactions to foods are continuing to occur, and better characterization might lead to better prevention, and peanuts and tree nuts accounted for more than 90% of the fatalities.
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Clinical features and severity grading of anaphylaxis

TL;DR: A simple grading system and definition of anaphylaxis has potential value for defining reaction severity in clinical practice and research settings and appears to be the major determinants of reaction severity.
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Advances in H1-Antihistamines

TL;DR: There are clinically relevant differences among H1-antihistamines in their pharmacology and safety profiles in allergic rhinoconjunctivitis and chronic urticaria.
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