Journal ArticleDOI
Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.
Hugh A. Sampson,Anne Muñoz-Furlong,Ronna L. Campbell,N. Franklin Adkinson,S. Allan Bock,Amy M. Branum,Simon G A Brown,Carlos A. Camargo,Rita K. Cydulka,Stephen J. Galli,Jane Gidudu,Rebecca S. Gruchalla,Allen D. Harlor,David L. Hepner,Lawrence M. Lewis,Phillip Lieberman,Dean D. Metcalfe,Robert E. O'Connor,Antonella Muraro,Amanda Rudman,Cara Schmitt,Debra Scherrer,F. Estelle R. Simons,Stephen Thomas,Joseph P. Wood,Wyatt W. Decker +25 more
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TLDR
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis, so representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition.Abstract:
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis. In July 2005, the National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network convened a second meeting on anaphylaxis, which included representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition of anaphylaxis, establish clinical criteria that would accurately identify cases of anaphylaxis with high precision, further review the evidence on the most appropriate management of anaphylaxis, and outline the research needs in this area.read more
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Low end-tidal CO2 as a real-time severity marker of intra-anaesthetic acute hypersensitivity reactions.
Aurélie Gouel-Chéron,Aurélie Gouel-Chéron,L. de Chaisemartin,Friederike Jönsson,Friederike Jönsson,Pascale Nicaise-Roland,Vanessa Granger,A. Sabahov,M-T Guinnepain,Sylvie Chollet-Martin,Pierre Bruhns,Pierre Bruhns,C. Neukirch,Dan Longrois +13 more
TL;DR: An etCO2 value below 2.6 kPa (20 mm Hg) could be useful for prompt diagnosis of severe intra-anaesthetic AHR, and could facilitate early treatment with titrated doses of epinephrine.
Journal ArticleDOI
The Genetic Basis and Clinical Impact of Hereditary Alpha-Tryptasemia.
TL;DR: Hereditary alpha-tryptasemia (HαT) is an autosomal dominant genetic trait found in 4% to 6% of the general population and defined by excess copies of alpha tryptase at TPSAB1 as discussed by the authors.
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A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning
Geoffrey K. Isbister,Michael A. Downes,Kylie Mcnamara,Ingrid Berling,Ian M Whyte,Colin B. Page +5 more
TL;DR: A 2-phase acetylcysteine infusion protocol results in a fewer reactions in patients with toxic paracetamol concentrations, but is not justified in patientsWith low-risk paracetmol concentrations.
Journal ArticleDOI
Characterization of aspirin allergies in patients with coronary artery disease
TL;DR: Histories of aspirin reactions in patients with CAD are uncommon, occurring in only 1.5% of the study population, and the 21% of patients with histories compatible with aspirin hypersensitivities can be challenged and, if the results are positive, successfully desensitized.
Journal ArticleDOI
A brief psychological intervention for mothers of children with food allergy can change risk perception and reduce anxiety: Outcomes of a randomized controlled trial
Robert J. Boyle,Robert J. Boyle,Thisanayagam Umasunthar,Thisanayagam Umasunthar,Jared G. Smith,Heather Hanna,Heather Hanna,Annabella Procktor,Annabella Procktor,Katherine W. Phillips,Katherine W. Phillips,Camila Pinto,Camila Pinto,Claudia Gore,Claudia Gore,Helen E. Cox,Helen E. Cox,John O. Warner,John O. Warner,Bea Vickers,Matthew Hodes,Matthew Hodes +21 more
TL;DR: Mothers of children with food allergy have increased anxiety, which may be influenced by healthcare professionals’ communication of risk.
References
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Journal ArticleDOI
Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents
TL;DR: Six children and adolescents who died of anaphylactic reactions to foods and seven others who nearly died and required intubation were identified and the failure to recognize the severity of these reactions and to administer epinephrine promptly increases the risk of a fatal outcome.
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Fatalities due to anaphylactic reactions to foods.
TL;DR: Fatal anaphylactic reactions to foods are continuing to occur, and better characterization might lead to better prevention, and peanuts and tree nuts accounted for more than 90% of the fatalities.
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Clinical features and severity grading of anaphylaxis
TL;DR: A simple grading system and definition of anaphylaxis has potential value for defining reaction severity in clinical practice and research settings and appears to be the major determinants of reaction severity.
Journal ArticleDOI
Symposium on the Definition and Management of Anaphylaxis: Summary report
Hugh A. Sampson,Anne Muñoz-Furlong,S. Allan Bock,Cara Schmitt,Robert Bass,Badrul A. Chowdhury,Wyatt W. Decker,Terence J. Furlong,Stephen J. Galli,David B.K. Golden,Rebecca S. Gruchalla,Allen D. Harlor,David L. Hepner,Marilyn Howarth,Allen P. Kaplan,Jerrold H. Levy,Lawrence M. Lewis,Phillip Lieberman,Dean D. Metcalfe,Ramon Murphy,Susan M. Pollart,Richard S. Pumphrey,Lanny J. Rosenwasser,F. Estelle R. Simons,Joseph P. Wood,Carlos A. Camargo +25 more
TL;DR: This dissertation aims to provide a history of medical marijuana use in the United States and Canada over a 40-year period from 1989 to 2002, with a focus on the period up to and including the year ending in 2002.
Journal ArticleDOI
Advances in H1-Antihistamines
TL;DR: There are clinically relevant differences among H1-antihistamines in their pharmacology and safety profiles in allergic rhinoconjunctivitis and chronic urticaria.