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Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.

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TLDR
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis, so representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition.
Abstract
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis. In July 2005, the National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network convened a second meeting on anaphylaxis, which included representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition of anaphylaxis, establish clinical criteria that would accurately identify cases of anaphylaxis with high precision, further review the evidence on the most appropriate management of anaphylaxis, and outline the research needs in this area.

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Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine

TL;DR: It is recommended that children receiving more than 1 injection of epinephrine should be observed for 24 hours, because it seems that children with requiring more than 2 injections of epinphrine might be have biphasic reactions.
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Predicting the outcome of oral food challenges with hen's egg through skin test end-point titration.

TL;DR: Background Oral food challenge is the diagnostic ‘gold standard’ of food allergies but it is laborious and time consuming, and attempts to predict a positive OFC through specific IgE assays or conventional skin tests so far gave suboptimal results.
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Clinical features of adult and pediatric anaphylaxis in Taiwan.

TL;DR: It is concluded that anaphylaxis in Taiwan appears to be increasing, just as in the West, but shows a different clinical picture; medication rather than food was the most common cause of anaphYLaxis in the population.
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Characterization of Anaphylaxis After Ecallantide Treatment of Hereditary Angioedema Attacks

TL;DR: Anaphylaxis episodes after subcutaneous ecallantide exposure have clinical features suggestive of type I hypersensitivity reactions, however, anti-ecallantides or anti-P pastoris IgE antibody status was not found to be reliably associated with anaphyl axis.
Journal Article

Severe immediate type hypersensitivity reactions in 105 German adults: when to diagnose anaphylaxis.

TL;DR: The application of the newly proposed diagnostic criteria did not identify as many patients with severe immediate-type reactions as the graded score currently employed for diagnosis of anaphylaxis in Germany.
References
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Journal ArticleDOI

Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents

TL;DR: Six children and adolescents who died of anaphylactic reactions to foods and seven others who nearly died and required intubation were identified and the failure to recognize the severity of these reactions and to administer epinephrine promptly increases the risk of a fatal outcome.
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Fatalities due to anaphylactic reactions to foods.

TL;DR: Fatal anaphylactic reactions to foods are continuing to occur, and better characterization might lead to better prevention, and peanuts and tree nuts accounted for more than 90% of the fatalities.
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Clinical features and severity grading of anaphylaxis

TL;DR: A simple grading system and definition of anaphylaxis has potential value for defining reaction severity in clinical practice and research settings and appears to be the major determinants of reaction severity.
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Advances in H1-Antihistamines

TL;DR: There are clinically relevant differences among H1-antihistamines in their pharmacology and safety profiles in allergic rhinoconjunctivitis and chronic urticaria.
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