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Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.

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TLDR
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis, so representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition.
Abstract
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis. In July 2005, the National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network convened a second meeting on anaphylaxis, which included representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition of anaphylaxis, establish clinical criteria that would accurately identify cases of anaphylaxis with high precision, further review the evidence on the most appropriate management of anaphylaxis, and outline the research needs in this area.

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Citations
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Epinephrine auto-injectors: is needle length adequate for delivery of epinephrine intramuscularly?

TL;DR: The needle on epinephrine auto-injectors is not long enough to reach the muscle in a significant number of children, and increasing the needle length on the auto- injectors would increase the likelihood that more children receive epinphrine by the recommended intramuscular route.
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Anaphylaxis epidemic: fact or fiction?

TL;DR: In this issue of the Journal, in a retrospective population-based study, Decker et al report the incidence of anaphylaxis from 1990 to 2000 in Olmstead County, Minnesota, as 49.8/100,000 personyears, and note that during this decade, the incidence varied from year to year.
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Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.

Jean Bousquet, +179 more
TL;DR: In this article, the authors generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis and chronic urticaria and atopic dermatitis) in order to have a unified definition of severity, control and risk, usable in most situations.
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Pathophysiology of anaphylaxis.

TL;DR: Recent advances will enhance understanding of the pathophysiology of anaphylaxis and might have future implications for diagnosis and management.
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Anaphylaxis to iodinated contrast media: clinical characteristics related with development of anaphylactic shock.

TL;DR: RCM induced anaphylactic shock is related to multiple exposures to RCM and most patients showed skin test positivity toRCM, according to the accompanying hypotension.
References
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Journal ArticleDOI

Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents

TL;DR: Six children and adolescents who died of anaphylactic reactions to foods and seven others who nearly died and required intubation were identified and the failure to recognize the severity of these reactions and to administer epinephrine promptly increases the risk of a fatal outcome.
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Fatalities due to anaphylactic reactions to foods.

TL;DR: Fatal anaphylactic reactions to foods are continuing to occur, and better characterization might lead to better prevention, and peanuts and tree nuts accounted for more than 90% of the fatalities.
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Clinical features and severity grading of anaphylaxis

TL;DR: A simple grading system and definition of anaphylaxis has potential value for defining reaction severity in clinical practice and research settings and appears to be the major determinants of reaction severity.
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Advances in H1-Antihistamines

TL;DR: There are clinically relevant differences among H1-antihistamines in their pharmacology and safety profiles in allergic rhinoconjunctivitis and chronic urticaria.
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