Journal ArticleDOI
Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.
Hugh A. Sampson,Anne Muñoz-Furlong,Ronna L. Campbell,N. Franklin Adkinson,S. Allan Bock,Amy M. Branum,Simon G A Brown,Carlos A. Camargo,Rita K. Cydulka,Stephen J. Galli,Jane Gidudu,Rebecca S. Gruchalla,Allen D. Harlor,David L. Hepner,Lawrence M. Lewis,Phillip Lieberman,Dean D. Metcalfe,Robert E. O'Connor,Antonella Muraro,Amanda Rudman,Cara Schmitt,Debra Scherrer,F. Estelle R. Simons,Stephen Thomas,Joseph P. Wood,Wyatt W. Decker +25 more
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TLDR
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis, so representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition.Abstract:
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis. In July 2005, the National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network convened a second meeting on anaphylaxis, which included representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition of anaphylaxis, establish clinical criteria that would accurately identify cases of anaphylaxis with high precision, further review the evidence on the most appropriate management of anaphylaxis, and outline the research needs in this area.read more
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Anaphylaxis: Recognizing Risk and Targeting Treatment
TL;DR: In a Clinical Commentary review in this theme issue of the journal, Turner et al present a unique look into the details of the published studies on fatal anaphylaxis, revealing variation in the outcomes and relative risk with different causes and in different settings.
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Management of anaphylaxis in schools: Evaluation of an epinephrine auto-injector (EpiPen®) use by school personnel and comparison of two approaches of soliciting participation
Nha Uyen Nguyen Luu,Nha Uyen Nguyen Luu,Lisa Cicutto,Lianne Soller,Lawrence Joseph,Susan Waserman,Yvan St-Pierre,Ann E. Clarke +7 more
TL;DR: Selection bias is suspected as school personnel who were fully informed of the purpose of the assessment were less likely to participate and those who participated among the fully informed were more likely to earn perfect scores and identify anaphylaxis.
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Natalizumab-related anaphylactoid reactions in MS patients are associated with HLA class II alleles
Belén de la Hera,Elena Urcelay,David Brassat,Andrew T. Chan,Angela Vidal-Jordana,Anke Salmen,Luisa M. Villar,J.C. Álvarez-Cermeño,G Izquierdo,Oscar Fernandez,Begoña Oliver,Albert Saiz,Jose Ramón Ara,Ana G. Vigo,Rafael Arroyo,Virginia Meca,Sunny Malhotra,Nicolás Fissolo,Alejandro Horga,Xavier Montalban,Manuel Comabella +20 more
TL;DR: HLA-DRB1 genotyping before natalizumab treatment may help neurologists to identify patients with MS at risk for developing serious systemic hypersensitivity reactions associated with natalIZumab administration.
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Update on epinephrine for the treatment of anaphylaxis.
TL;DR: Epinephrine is the primary therapy for anaphylaxis, yet studies show that it is underutilized, and by addressing the contributory factors that have been identified, acute and long-term care of individuals with this potentially life-threatening disorder can be optimized.
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Triggers, risk factors and clinico-pathological features of urticaria in dogs – a prospective observational study of 24 cases
TL;DR: This is the first study describing the trigger factors and clinico‐pathological features of dogs with urticaria in veterinary medicine and Insects, food and drugs were the most frequently detected triggers.
References
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Journal ArticleDOI
Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents
TL;DR: Six children and adolescents who died of anaphylactic reactions to foods and seven others who nearly died and required intubation were identified and the failure to recognize the severity of these reactions and to administer epinephrine promptly increases the risk of a fatal outcome.
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Fatalities due to anaphylactic reactions to foods.
TL;DR: Fatal anaphylactic reactions to foods are continuing to occur, and better characterization might lead to better prevention, and peanuts and tree nuts accounted for more than 90% of the fatalities.
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Clinical features and severity grading of anaphylaxis
TL;DR: A simple grading system and definition of anaphylaxis has potential value for defining reaction severity in clinical practice and research settings and appears to be the major determinants of reaction severity.
Journal ArticleDOI
Symposium on the Definition and Management of Anaphylaxis: Summary report
Hugh A. Sampson,Anne Muñoz-Furlong,S. Allan Bock,Cara Schmitt,Robert Bass,Badrul A. Chowdhury,Wyatt W. Decker,Terence J. Furlong,Stephen J. Galli,David B.K. Golden,Rebecca S. Gruchalla,Allen D. Harlor,David L. Hepner,Marilyn Howarth,Allen P. Kaplan,Jerrold H. Levy,Lawrence M. Lewis,Phillip Lieberman,Dean D. Metcalfe,Ramon Murphy,Susan M. Pollart,Richard S. Pumphrey,Lanny J. Rosenwasser,F. Estelle R. Simons,Joseph P. Wood,Carlos A. Camargo +25 more
TL;DR: This dissertation aims to provide a history of medical marijuana use in the United States and Canada over a 40-year period from 1989 to 2002, with a focus on the period up to and including the year ending in 2002.
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Advances in H1-Antihistamines
TL;DR: There are clinically relevant differences among H1-antihistamines in their pharmacology and safety profiles in allergic rhinoconjunctivitis and chronic urticaria.