Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population
Nasser M. Al-Daghri,R. Chetty,Philip G. McTernan,K. Al-Rubean,Omar S. Al-Attas,Alan Jones,Sudhesh Kumar +6 more
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TLDR
The findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD, and demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients.Abstract:
Aims
Resistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes (T2DM). This study examines the association between human serum resistin, T2DM and coronary heart disease.read more
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Resistin, Adiponectin, and Risk of Heart Failure: The Framingham Offspring Study
David S. Frankel,Ramachandran S. Vasan,Ralph B. D'Agostino,Emelia J. Benjamin,Daniel Levy,Thomas J. Wang,James B. Meigs +6 more
TL;DR: Increased circulating concentrations of resistin were associated with incident heart failure, even after accounting for prevalent coronary heart disease, obesity, and measures of insulin resistance and inflammation, and suggest a role for resistin in human disease and a novel pathway to heart failure.
Journal ArticleDOI
Resistin is secreted from macrophages in atheromas and promotes atherosclerosis.
Hye Seung Jung,Ki Ho Park,Young Min Cho,Young Min Cho,Sung Soo Chung,Hyun Ju Cho,Soo Youn Cho,Sang Joon Kim,Seong Yeon Kim,Hong Kyu Lee,Kyong Soo Park,Kyong Soo Park +11 more
TL;DR: Macrophages infiltrating atherosclerotic aneurysms secrete resistin, and resistin affects endothelial function and VSMC migration, and may contribute to atherogenesis by virtue of its effects on vascular endothelial cells and smooth muscle cells in humans.
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Adipokine inflammation and insulin resistance : the role of glucose, lipids and endotoxin
TL;DR: How nutrients such as glucose and lipids can influence adipokine inflammation and consequently insulin resistance directly through their effects on secretion of adipocytokines (TNFα, IL6 and resistin as well as indirectly through increases in endotoxin is discussed.
Journal Article
Role of resistin in inflammation and inflammation-related diseases.
Shanshan Pang,Yingying Le +1 more
TL;DR: Recently, resistin was found to be relevant to inflammation and inflammation-related diseases like atherosclerosis and arthritis and was firstly proposed to be involved in insulin resistance and type 2 diabetes.
Journal ArticleDOI
Resistin- and Obesity-associated metabolic diseases.
TL;DR: Given the emerging interrelationship between inflammation and metabolic disease, hyperresistinemia may be a biomarker, and/or a mediator, of metabolic and inflammatory diseases in humans as well as in rodents.
References
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Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
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The hormone resistin links obesity to diabetes
Claire M. Steppan,Shannon T. Bailey,Savitha Bhat,Elizabeth J. Brown,Ronadip R. Banerjee,Christopher M. Wright,Hiralben R. Patel,Rexford S. Ahima,Mitchell A. Lazar +8 more
TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.
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Inflammation: the link between insulin resistance, obesity and diabetes.
TL;DR: The increased concentrations of TNF-alpha and IL-6, associated with obesity and type 2 diabetes, might interfere with insulin action by suppressing insulin signal transduction, which might interfering with the anti-inflammatory effect of insulin, which in turn might promote inflammation.
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Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes.
TL;DR: Further research is needed to confirm and clarify the role of innate immunity in type 2 diabetes, particularly the extent to which inflammation in type 1 diabetes is a primary abnormality or partly secondary to hyperglycemia, obesity, atherosclerosis, or other common features of the disease.
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Minireview: The adipocyte - At the crossroads of energy homeostasis, inflammation, and atherosclerosis
TL;DR: The role of adipose tissue as an endocrine organ is highlighted focusing on some of the recent advances in the identification and pharmacological characterization of adipokines as well as their regulation in the context of obesity and insulin-resistant states.