Journal ArticleDOI
Signal amplification using functional nanomaterials for biosensing
Jianping Lei,Huangxian Ju +1 more
TLDR
This tutorial review will focus on recent significant advances in signal amplification strategies combining the cross-disciplines of chemistry, biology, and materials science, and highlight some elegant applications of biofunctional nanomaterials as excellent electronic or optical signal tags in ultrasensitive bioanalysis.Abstract:
Signal amplification based on biofunctional nanomaterials has recently attracted considerable attention due to the need for ultrasensitive bioassays and the trend towards miniaturized assays. The biofunctional nanomaterials can not only produce a synergic effect among catalytic activity, conductivity and biocompatibility to accelerate the signal transduction, but also provide amplified recognition events by high loading of signal tags, leading to a highly sensitive and specific biosensing. Most importantly, nanoscaled materials are in direct contact with the environment, which permits them to act as chemical and biological sensors in single-molecule detection of biomolecules. In this tutorial review, we will focus on recent significant advances in signal amplification strategies combining the cross-disciplines of chemistry, biology, and materials science, and highlight some elegant applications of biofunctional nanomaterials as excellent electronic or optical signal tags in ultrasensitive bioanalysis. The biofunctional nanomaterials-based biosensing opens a series of concepts for basic research and offers new tools for detection of trace amounts of a wide variety of analytes in clinical, environmental, and industrial applications.read more
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Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Hui Wei,Erkang Wang +1 more
TL;DR: This review discusses various nanomaterials that have been explored to mimic different kinds of enzymes and covers their kinetics, mechanisms and applications in numerous fields, from biosensing and immunoassays, to stem cell growth and pollutant removal.
Journal ArticleDOI
Applications of nanotechnology in water and wastewater treatment
TL;DR: Recent development in nanotechnology for water and wastewater treatment is reviewed, covering candidate nanomaterials, properties and mechanisms that enable the applications, advantages and limitations as compared to existing processes, and barriers and research needs for commercialization.
Journal ArticleDOI
Nanomaterials for biosensing applications: a review
TL;DR: This review summarizes in a non-exhaustive way the advantages of nanomaterials by focusing on nano-objects which provide further beneficial properties than “just” an enhanced surface area.
Journal ArticleDOI
Core–Shell Nanoparticle-Enhanced Raman Spectroscopy
TL;DR: The concept of shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) in detail is introduced in detail because it overcomes the long-standing limitations of material and morphology generality encountered in traditional SERS.
Journal ArticleDOI
Cancer biomarker detection: recent achievements and challenges
Li-Li Wu,Xiaogang Qu +1 more
TL;DR: An overview of recent advances in cancer biomarker detection is provided and several representative examples using different approaches for each biomarker demonstrate that the multidisciplinary technology-based cancer diagnostics are becoming an increasingly relevant alternative to traditional techniques.
References
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Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Lizeng Gao,Jie Zhuang,Leng Nie,Jinbin Zhang,Yu Zhang,Ning Gu,Taihong Wang,Jing Feng,Dongling Yang,Sarah Perrett,Xiyun Yan +10 more
TL;DR: It is reported that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools.
Journal ArticleDOI
Shell-isolated nanoparticle-enhanced Raman spectroscopy
Jian-Feng Li,Yi-Fan Huang,Yong( Georgia Inst Technol Sch Mat Sci Engn) Ding,Zhilin Yang,Song Bo Li,Xiao-Shun Zhou,Fengru Fan,Fengru Fan,Wei Zhang,Zhi-You Zhou,De-Yin Wu,Bin Ren,Zhong Lin( Georgia Inst Technol Sch Mat Sci Engn) Wang,Zhong-Qun Tian +13 more
TL;DR: Shell-isolated nanoparticle-enhanced Raman spectroscopy is reported, in which the Raman signal amplification is provided by gold nanoparticles with an ultrathin silica or alumina shell, which significantly expands the flexibility of SERS for useful applications in the materials and life sciences, as well as for the inspection of food safety, drugs, explosives and environment pollutants.
Journal ArticleDOI
Noncovalent Sidewall Functionalization of Single-Walled Carbon Nanotubes for Protein Immobilization
TL;DR: Single-walled carbon nanotubes are molecular wires that exhibit interesting structural, mechanical, electrical, and electromechanical properties that make for an ideal miniaturized sensor.
Journal ArticleDOI
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging
TL;DR: The design parameters that affect MNP performance in vivo are summarized, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers.
Journal ArticleDOI
Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles
Huixiang Li,Lewis J. Rothberg +1 more
TL;DR: It is found that single- and double-stranded oligonucleotides have different propensities to adsorb on gold nanoparticles in colloidal solution and this observation is used to design a hybridization assay based on color changes associated with gold aggregation.