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Signal Decomposition for X-ray Dark-Field Imaging

TLDR
This paper presents a novel--and to the knowledge the first--algorithm for isolating small-angle scattering in dark-field images, which greatly improves their interpretability and promises a greatly enhanced diagnostic value of dark- field images.
Abstract
Grating-based X-ray dark-field imaging is a new imaging modality. It allows the visualization of structures at micrometer scale due to small-angle scattering of the X-ray beam. However, reading dark-field images is challenging as absorption and edge-diffraction effects also contribute to the dark-field signal, without adding diagnostic value. In this paper, we present a novel – and to our knowledge the first – algorithm for isolating small-angle scattering in dark-field images, which greatly improves their interpretability. To this end, our algorithm utilizes the information available from the absorption and differential phase images to identify clinically irrelevant contributions to the dark-field image. Experimental results on phantom and ex-vivo breast data promise a greatly enhanced diagnostic value of dark-field images.

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Citations
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Journal ArticleDOI

Time and Mechanism of Nanoparticle Functionalization by Macromolecular Ligands during Pulsed Laser Ablation in Liquids.

TL;DR: Complementary ex situ characterization confirms the overall size quenching ability of both additive types NaCl and PVP, and concludes an alternative interaction mechanism with ablated nanoparticles compared to the electrolyte NaCl, probably outside of the cavitation bubble, in the surrounding liquid phase.
Journal ArticleDOI

A beam hardening and dispersion correction for x-ray dark-field radiography

TL;DR: The authors show that the influence of and dispersion can be quantified by simulation and, thus, measured image data can be corrected and an increase in contrast is shown compared to the original image, which might simplify a further image-based diagnosis.
Journal ArticleDOI

Scalable, large area compound array refractive lens for hard X-rays

TL;DR: In this article, a 2D Compound Array Refractive Lens (CARL) for multi-contrast X-ray imaging is presented, which consists of six stacked polyimide foils with each displaying a two-dimensional array of lenses with a 65μm pitch aiming for a sensitivity on sub-micrometer structures.
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A Shack-Hartmann sensor for single-shot multi-contrast imaging with hard X-rays

TL;DR: An array of compound refractive X-ray lenses (CRL) with 20 × 20 lenslets, a focal distance of 20cm and a visibility of 0.93 is presented in this article.
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Review and experimental verification of x-ray dark-field signal interpretations with respect to quantitative isotropic and anisotropic dark-field computed tomography.

TL;DR: In this paper, the Yashiro-Lynch model was used to describe the anisotropic signals of fibrous objects in X-ray and neutron dark-field images and was experimentally verified both in radiographic and tomographic imaging in a monochromatic synchrotron setting.
References
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Journal ArticleDOI

Fast and robust fixed-point algorithms for independent component analysis

TL;DR: Using maximum entropy approximations of differential entropy, a family of new contrast (objective) functions for ICA enable both the estimation of the whole decomposition by minimizing mutual information, and estimation of individual independent components as projection pursuit directions.
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Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources

TL;DR: In this article, a setup consisting of three transmission gratings can efficiently yield quantitative differential phase-contrast images with conventional X-ray tubes, which can be scaled up to large fields of view.
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Phase-contrast imaging using polychromatic hard X-rays

TL;DR: In this paper, a simplified scheme for phase-contrast imaging based on an X-ray source having high spatial (but essentially no chromatic) coherence is presented. But the method is not suitable for large areas of irradiation, and it can operate with a lower absorbed dose than traditional Xray imaging techniques, and should find broad application in clinical, biological and industrial settings.
Journal ArticleDOI

On the origin of visibility contrast in x-ray Talbot interferometry

TL;DR: The visibility-reduction contrast observed by x-ray grating interferometry can be understood in relation to the structural parameters of the microstructures, and the relation between the three parameters and the features of the micron-sized structures is discussed.
Journal ArticleDOI

On a dark-field signal generated by micrometer-sized calcifications in phase-contrast mammography

TL;DR: In this paper, it was shown that a distribution of micrometer-sized calcifications in the human breast which are not visible in clinical x-ray mammography at diagnostic dose levels can produce a significant dark-field signal in a grating-based xray phase-contrast imaging setup with a tungsten anode xray tube operated at 40 kVp.
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