Sphingosine-1-phosphate signaling and its role in disease
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TLDR
The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer, atherosclerosis, diabetes and osteoporosis.About:
This article is published in Trends in Cell Biology.The article was published on 2012-01-01 and is currently open access. It has received 867 citations till now. The article focuses on the topics: Sphingosine kinase & SPHK2.read more
Citations
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The pathogenesis and treatment of the `Cytokine Storm' in COVID-19.
Qing Ye,Bili Wang,Jianhua Mao +2 more
TL;DR: This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.
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Revisiting STAT3 signalling in cancer: new and unexpected biological functions
TL;DR: Well known for its role in tumour cell proliferation, survival, invasion and immunosuppression, JAK–STAT3 signalling also promotes cancer through inflammation, obesity, stem cells and the pre-metastatic niche.
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Cytokine storm and sepsis disease pathogenesis
TL;DR: The pathophysiology of the cytokine storm is summarized; the type, effects, and kinetics of cytokine production are described; and new promising therapeutic strategies focusing on the endothelium, as a source and a target of cytokines are described.
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The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
Morgan O'Hayre,José Vázquez-Prado,Irina Kufareva,Eric Stawiski,Tracy M. Handel,Somasekar Seshagiri,J. Silvio Gutkind +6 more
TL;DR: Deep sequencing studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment.
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Diabetes, oxidative stress and therapeutic strategies
TL;DR: It appears important to develop new compounds that target key vascular ROS producing enzymes and mimic endogenous antioxidants, which might prove clinically relevant in preventing the development and/or retarding the progression of diabetes associated with vascular diseases.
References
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Sphingosine-1-phosphate: an enigmatic signalling lipid
Sarah Spiegel,Sheldon Milstien +1 more
TL;DR: The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions.
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Pathogenesis of osteoporosis: concepts, conflicts, and prospects
TL;DR: This review examines the fundamental pathogenetic mechanisms underlying osteoporosis, which include: (a) failure to achieve a skeleton of optimal strength during growth and development; (b) excessive bone resorption resulting in loss of bone mass and disruption of architecture; and (c) Failure to replace lost bone due to defects in bone formation.
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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.
Olivier Cuvillier,Grisha Pirianov,Burkhard Kleuser,Philip G. Vanek,Omar A. Coso,J. Silvio Gutkind,Sarah Spiegel +6 more
TL;DR: It is reported that sphingosine-1-phosphate prevents the appearance of the key features of apoptosis, namely intranucleosomal DNA fragmentation and morphological changes, which result from increased concentrations of ceramide.
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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
Volker Brinkmann,Andreas Billich,Thomas Baumruker,Peter Heining,Robert Schmouder,Gordon Francis,Shreeram Aradhye,Pascale Burtin +7 more
TL;DR: The discovery and development of fingolimod is described, which was approved by the US Food and Drug Administration in September 2010 as a first-line treatment for relapsing forms of multiple sclerosis, thereby becoming the first oral disease-modifying therapy to be approved for multiple sclerosis in the United States.
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Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens.
Ana Olivera,Sarah Spiegel +1 more
TL;DR: It is reported that activation of sphingosine kinase and the formation of sphedosine-1-phosphate are important in the signal transduction pathways activated by the potent mitogens platelet-derived growth factor (PDGF) and fetal calf serum (FCS).