SR-BI-mediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux
Tamara A. Pagler,Sebastian Rhode,Angelika Neuhofer,Hildegard Laggner,W. Strobl,Claudia Hinterndorfer,Ivo Volf,Margit Pavelka,Erik Eckhardt,Deneys R. van der Westhuyzen,Gerhard J. Schütz,Herbert Stangl +11 more
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TLDR
Evidence that HDL retroendocytosis represents one of the pathways for cholesterol efflux is presented, as well as three physiologically relevant cell systems, including the liver cell line HepG2, the adrenal cell line Y1BS1, and phorbol myristate acetate-differentiated THP-1 cells as a model for macrophages.About:
This article is published in Journal of Biological Chemistry.The article was published on 2006-04-21 and is currently open access. It has received 130 citations till now. The article focuses on the topics: Low-density lipoprotein & Liver cell.read more
Citations
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Journal ArticleDOI
Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.
TL;DR: The structure and function of SR-BI, the importance of the selective cholesterol transport pathway in providing cholesterol substrate for steroid biosynthesis and the role of two key proteins, StAR and PBR/TSO in facilitating cholesterol delivery to inner mitochondrial membrane sites are discussed.
Journal ArticleDOI
Lutein, Zeaxanthin, and meso-Zeaxanthin: The Basic and Clinical Science Underlying Carotenoid-based Nutritional Interventions against Ocular Disease
Paul S. Bernstein,Binxing Li,Preejith P. Vachali,Aruna Gorusupudi,Rajalekshmy Shyam,Bradley S. Henriksen,John M. Nolan +6 more
TL;DR: The chemistry, biochemistry, biophysics, and physiology of these yellow pigments that are specifically concentrated in the macula lutea are examined through the means of high-affinity binding proteins and specialized transport and metabolic proteins where they play important roles as short-wavelength light-absorbers and localized, efficient antioxidants in a region at high risk for light-induced oxidative stress.
Journal ArticleDOI
High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI.
Marlène Dreux,Marlène Dreux,Thomas Pietschmann,Christelle Granier,Christelle Granier,Cécile Voisset,Sylvie Ricard-Blum,Philippe E. Mangeot,Zhen-Yong Keck,Steven K. H. Foung,Ngoc Vu-Dac,Jean Dubuisson,Ralf Bartenschlager,Dimitri Lavillette,Dimitri Lavillette,François-Loïc Cosset,François-Loïc Cosset +16 more
TL;DR: It is found that HDL activation of target cells strongly stimulates cell entry of viral particles by accelerating their endocytosis, thereby suppressing a 1-h time lag during which cell-bound virions are not internalized and can be targeted by antibodies.
Journal ArticleDOI
Mechanisms for cellular cholesterol transport : Defects and human disease
TL;DR: Because of the organizing potential of cholesterol in membranes, disturbances in cellular cholesterol transport have implications for a wide variety of human diseases, of which selected examples are given.
Review 2058 The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?
Attilio Rigotti,David E. Cohen,Silvana Zanlungo,Nicolas G. Bazan,Jorgelina M. Calandria,Charles N. Serhan,Daphna Weissglas-Volkov,Päivi Pajukanta,Menno Vergeer,Adriaan G. Holleboom,John J. P. Kastelein,Jan Albert,Kuivenhoven +12 more
TL;DR: A significant number of animal studies and clinical trials support an atheroprotective role for HDL; however, most of these findings were obtained in the context of marked changes in other plasma lipids so future research remains essential to prove the HDL hypothesis correct.
References
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Journal ArticleDOI
Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
TL;DR: With a single preparative ultracentrifugation, immunologically pure high density lipoproteins can be isolated from large volumes of serum.
Journal ArticleDOI
Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Susan L. Acton,Attilio Rigotti,Katherine T. Landschulz,Shangzhe Xu,Helen H. Hobbs,Monty Krieger +5 more
TL;DR: It is shown that the class B scavenger receptor SR-BI is an HDL receptor, which mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.
Journal ArticleDOI
Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
Angela Brooks-Wilson,Michel Marcil,Susanne M. Clee,Lin-Hua Zhang,Kirsten Roomp,M. Van Dam,Lu Yu,C. Brewer,Jennifer A. Collins,H.O. Molhuizen,O. Loubser,B. F. F. Ouelette,Keith Fichter,K. J. D. Ashbourne-Excoffon,Christoph Wilhelm Sensen,Stephen W. Scherer,Stephanie Mott,Maxime Denis,Duane Martindale,J J Frohlich,Kenneth Morgan,Ben F. Koop,Simon N. Pimstone,J.J.P. Kastelein,Jacques Genest,Michael R. Hayden +25 more
TL;DR: Two Tangier disease families are identified, confirmed 9q31 linkage and the disease locus is refined to a limited genomic region containing the gene encoding the ATP-binding cassette transporter (ABC1), indicating that TD and FHA are allelic.
Book ChapterDOI
Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
TL;DR: Study of the cell surface binding, internalization, and metabolism of low-density lipoprotein (LDL) in cultured cells have provided useful information regarding the general aspects of receptor-mediated endocytosis and three classes of mutant alleles at the LDL receptor locus have been deduced.
Journal ArticleDOI
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
Marek Bodzioch,Evelyn Orsó,Jochen Klucken,Thomas Langmann,Alfred Böttcher,Wendy Diederich,Wolfgang Drobnik,Stefan Barlage,Christa Büchler,Mustafa Porsch-Özcürümez,Wolfgang E. Kaminski,Harry W. Hahmann,Kurt Oette,Gregor Rothe,Charalampos Aslanidis,Karl J. Lackner,Gerd Schmitz +16 more
TL;DR: Evidence is presented that TD is caused by mutations in ABC1, encoding a member of the ATP-binding cassette (ABC) transporter family, located on chromosome 9q22–31, which has implications for the understanding of cellular HDL metabolism and reverse cholesterol transport, and its association with premature cardiovascular disease.