Structural Basis of Collagen Recognition by Integrin α2β1
Jonas Emsley,C. Graham Knight,Richard W. Farndale,Michael J. Barnes,Robert C. Liddington,Robert C. Liddington +5 more
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TLDR
The crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif is determined, suggesting both a basis for affinity regulation and a pathway for signal transduction.About:
This article is published in Cell.The article was published on 2000-03-31 and is currently open access. It has received 927 citations till now. The article focuses on the topics: Integrin alpha2.read more
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Integrins: Bidirectional, Allosteric Signaling Machines
TL;DR: Current structural and cell biological data suggest models for how integrins transmit signals between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link to the cytoskeleton and to signal transduction pathways.
Journal ArticleDOI
Cell migration: integrating signals from front to back.
Anne J. Ridley,Martin A. Schwartz,Keith Burridge,Richard A. Firtel,Mark H. Ginsberg,Gary G. Borisy,J. Thomas Parsons,Alan Rick Horwitz +7 more
TL;DR: The mechanisms underlying the major steps of migration and the signaling pathways that regulate them are described, and recent advances investigating the nature of polarity in migrating cells and the pathways that establish it are outlined.
Journal ArticleDOI
Collagen Structure and Stability
TL;DR: The fibrillar structure of type I collagen-the prototypical collagen fibril-has been revealed in detail and will guide further development of artificial collagenous materials for biomedicine and nanotechnology.
Journal ArticleDOI
Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand
Jian-Ping Xiong,Thilo Stehle,Rongguang Zhang,Andrzej Joachimiak,Matthias Frech,Simon L. Goodman,M. Amin Arnaout +6 more
TL;DR: The crystal structure of the extracellular segment of integrin αVβ3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence is reported and ligand binding induces small changes in the orientation of αV relative to β3.
Journal ArticleDOI
Structural Basis of Integrin Regulation and Signaling
TL;DR: This review focuses on integrin structure as it relates to affinity modulation, ligand binding, outside-in signaling, and cell surface distribution dynamics.
References
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Axel T. Brunger,Axel T. Brunger,Paul D. Adams,G M Clore,W. L. DeLano,Piet Gros,R.W. Grosse-Kunstleve,R.W. Grosse-Kunstleve,Jiansheng Jiang,J. Kuszewski,Michael Nilges,Navraj S. Pannu,Randy J. Read,Luke M. Rice,Thomas Simonson,Gregory L. Warren +15 more
TL;DR: The Crystallography & NMR System (CNS) as mentioned in this paper is a software suite for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy.
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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
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Integrins: versatility, modulation, and signaling in cell adhesion.
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AMoRe: an automated package for molecular replacement
TL;DR: In this paper, a new molecular-replacement package is presented, which is an improvement on conventional methods, based on more powerful algorithms and a new conception that enables automation and rapid solution.
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Raster3D Version 2.0. A program for photorealistic molecular graphics.
TL;DR: Raster3D Version 2.0 is a program suite for the production of photorealistic molecular graphics images, and is particularly suited for use in producing large raster images of macromolecules for output to a film recorder or high-quality color printer.