Studies of cellular proliferation in human leukemia. VI. The proliferative activity, generation time, and emergence time of neutrophilic granulocytes in chronic granulocytic leukemia.
Reads0
Chats0
TLDR
The proliferative kinetics of neutrophilic granulocytes were studied in 3 patients with typical chronic granulocytic leukemia by means of differential counts, mitotic indexes, and 3H‐thymidine labeling using autoradio‐graphic methods.Abstract:
The proliferative kinetics of neutrophilic granulocytes were studied in 3 patients with typical chronic granulocytic leukemia (CGL) by means of differential counts, mitotic indexes, and 3H-thymidine labeling using autoradio-graphic methods. The granulocyte precursors in CGL had lower mitotic and 3H-thymidine labeling indexes than the corresponding normal cells; their median grain count halving times were longer than normal in 2 patients and approximately normal in the third. The proliferative rates appeared similar in the marrow and spleen but the cells rarely divided in the blood. In one patient given a continuous intravenous 3H-thymidine infusion for 10 days, 100% of the granulocyte precursors were labeled. The minimum maturation time of CGL neutrophilics was approximately normal, but their average transit times through the myelocyte and later maturation compartments was prolonged. The overproduction of granulocytes appears mainly due to increased formation of myeloblasts; whether this is due to an increased rate of stem cell activation or whether the myeloblasts may themselves function to some extent as selfsustaining cells is unknown.read more
Citations
More filters
Journal ArticleDOI
Evolution of the Cancer Stem Cell Model
Antonija Kreso,John E. Dick +1 more
TL;DR: It is proposed that the genetic and CSC models of cancer can be harmonized by considering the role of genetic diversity and nongenetic influences in contributing to tumor heterogeneity.
Journal ArticleDOI
Cancer stem cells: an evolving concept
TL;DR: New insights are obtained into why the CSC concept is not universally applicable, as well as a new basis for understanding the complex evolution, phenotypic heterogeneity and therapeutic challenges of many human cancers.
Journal ArticleDOI
Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
TL;DR: It remains uncertain whether the stem cell model applies to many, or few, cancers due to questions about the robustness of cancer stem cell markers and the extent to which existing assays underestimate the frequency of tumorigenic cells.
Journal ArticleDOI
Clinical investigation of human alpha interferon in chronic myelogenous leukemia.
Moshe Talpaz,Hagop M. Kantarjian,Kenneth B. McCredie,Michael J. Keating,Jose M. Trujillo,Jordan U. Gutterman +5 more
TL;DR: It is concluded that human leukocyte alpha interferon effectively controls chronic myeloid leukemia and allows reappearance of diploid hemopoietic cells in some patients.
Journal ArticleDOI
Results of treatment of Ph'+ chronic myelogenous leukemia with an intensive treatment regimen (L-5 protocol)
I Cunningham,Timothy Gee,Monroe D. Dowling,Raju S.K. Chaganti,Roller B. Bailey,Seymour Hopfan,Lemuel Bowden,Alan D. Turnbull,William H. Knapper,Bayard D. Clarkson +9 more
TL;DR: Patients who have a reduction in Ph'+ cells in the marrow may survive longer than the average; also, the reduction occurs most frequently in patients who have relatively small spleens at diagnosis, and it may be reinduced in some patients with intensive chemotherapy.
References
More filters
Journal ArticleDOI
The kinetics of granulopoiesis in normal man.
TL;DR: A kinetic model for granulopoiesis, based on the studies with the DFP 32 label, is presented, which depicts myelocytes as approaching a self-perpetuating population of cells.
Journal ArticleDOI
Studies of Cellular Proliferation in Human Leukemia. I. Estimation of Growth Rates of Leukemic and Normal Hematopoietic Cells in Two Adults with Acute Leukemia Given Single Injections of Tritiated Thymidine
TL;DR: It is concluded that main reason leukemic blasts displace normal hematopoietic precursors in acute leukemia is that the blasts largely fail to differentiate.
Journal Article
Estimation of phases of the life cycle of leukemic cells from labeling in human beings in vivo with tritiated thymidine.
Journal ArticleDOI
Studies of cellular proliferation in human leukemia. III. Behavior of leukemic cells in three adults with acute leukemia given continuous infusions of 3H-thymidine for 8 or 10 days
TL;DR: Three adults with acute leukemia were given continuous infusions of 3H‐thymidine for 8 or 10 days and the data is consistent with the hypothesis that the leukemic cells behave as a self‐maintaining population.
Journal ArticleDOI
Granulocytopoiesis. ii. emergence and pattern of labeling of neutrophilic granulocytes in humans.
Theodor M. Fliedner,Theodor M. Fliedner,Eugene P. Cronkite,Sven-Åge Killmann,Sven-Åge Killmann,Victor P. Bond +5 more
TL;DR: The constancy of the findings suggest that there may be a constant input of cells with the index of labeling varying due to some synchrony of the precursor population(s).