Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man.
Keiji Sekiguchi,Noboru Obi +1 more
TLDR
In this paper, it was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of the drug in water, which can be used to adjust the therapeutic effect of medical compounds.Abstract:
1) Sulfathiazole forms eutectic mixtures with urea, l-ascorbic acid, acetamide, nicotinic acid, nicotinamide, or succinimide. It was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of sulfathiazole in water. 2) Sulfathiazole in a eutectic mixture with urea shows higher absorption and excretion after oral administration than ordinary sulfathiazole. 3) Since urea does not possess solubilizing action on sulfathiazole and also it does not enhance absorption of the drug physiologically, the accelerated absorption or excretion must be attributed to the physical state of sulfathiazole in its eutectic mixture with easily soluble compound, such as urea. 4) It is assumed that this new form of preparation will give a means of adjusting therapeutic effect of medical compounds.read more
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Phase behaviour analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP-K30 and PVP-VA64
Ilse Weuts,Dieter Kempen,Annelies Decorte,Geert Verreck,Jef Peeters,Marcus E. Brewster,Guy Van den Mooter +6 more
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The Application of Modeling and Prediction to the Formation and Stability of Amorphous Solid Dispersions
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Salt formation in solid dispersions consisting of polyacrylic acid as a carrier and three basic model compounds resulting in very high glass transition temperatures and constant dissolution properties upon storage.
Ilse Weuts,Dieter Kempen,Geert Verreck,Jef Peeters,Marcus E. Brewster,Norbert Blaton,Guy Van den Mooter +6 more
TL;DR: From the experimental results, it could be concluded that PAA is a suitable carrier in the formulation of stable solid dispersions for the basic compounds that were investigated.
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Prediction of poly(ethylene) glycol-drug eutectic compositions using an index based on the van't Hoff equation.
TL;DR: The index provides a useful screening tool for assessing the maximum drug loading in a drug-polymer eutectic/monotectic formulation.