Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man.
Keiji Sekiguchi,Noboru Obi +1 more
TLDR
In this paper, it was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of the drug in water, which can be used to adjust the therapeutic effect of medical compounds.Abstract:
1) Sulfathiazole forms eutectic mixtures with urea, l-ascorbic acid, acetamide, nicotinic acid, nicotinamide, or succinimide. It was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of sulfathiazole in water. 2) Sulfathiazole in a eutectic mixture with urea shows higher absorption and excretion after oral administration than ordinary sulfathiazole. 3) Since urea does not possess solubilizing action on sulfathiazole and also it does not enhance absorption of the drug physiologically, the accelerated absorption or excretion must be attributed to the physical state of sulfathiazole in its eutectic mixture with easily soluble compound, such as urea. 4) It is assumed that this new form of preparation will give a means of adjusting therapeutic effect of medical compounds.read more
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An overview on various approaches used for solubilization of poorly soluble drugs
TL;DR: The aim of this review is to improve the solubilization of poorly soluble drugs by using various approaches by physical and chemical modifications.
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Studies on hydrophobic drug-soluble carrier coprecitates (II)
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Studies on hydrophobic drug-soluble carrier coprecipitates(I): Dissolution characteristics of furosemide-polymer coprecipitates
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Some Properties of Diazepam-Polyethylene Glycol 6000 Solid Dispersions and their Modification in the Presence of Stearic Acid of Polysorbate 80
TL;DR: Physical mixtures and melts of diazepam and polyethylene glycol 6000 have been studied by Differential Scanning Calorimetry (DSC) and Differential Thermal Analysis (DTA).
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Preparation, characterization and in vitro and in vivo evaluation of a solid dispersion of Naringin.
Jingjing Wang,Xueyi Ye,Shiyuan Lin,Hanfu Liu,Yin Qiang,Hui Chen,Zhiming Jiang,Kefeng Zhang,Xiaoqun Duan,Yourui Xu +9 more
TL;DR: The solid dispersion (SD) is considered as a promising approach to enhance the dissolution rate and oral bioavailability of NA.