Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man.
Keiji Sekiguchi,Noboru Obi +1 more
Reads0
Chats0
TLDR
In this paper, it was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of the drug in water, which can be used to adjust the therapeutic effect of medical compounds.Abstract:
1) Sulfathiazole forms eutectic mixtures with urea, l-ascorbic acid, acetamide, nicotinic acid, nicotinamide, or succinimide. It was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of sulfathiazole in water. 2) Sulfathiazole in a eutectic mixture with urea shows higher absorption and excretion after oral administration than ordinary sulfathiazole. 3) Since urea does not possess solubilizing action on sulfathiazole and also it does not enhance absorption of the drug physiologically, the accelerated absorption or excretion must be attributed to the physical state of sulfathiazole in its eutectic mixture with easily soluble compound, such as urea. 4) It is assumed that this new form of preparation will give a means of adjusting therapeutic effect of medical compounds.read more
Citations
More filters
Polivinyl pyrrolidine-an approach to enhance the solubility and dissolution of valdecoxib tablets
TL;DR: In this paper, the authors used solvent evaporation method for the preparation and evaluation of solid dispersion of valdecoxib with a view to develop a fast release formulation of the drug using carriers such as polyvinyl pyrrolidine.
Preparation, characterization and evaluation of olmesartan medoxomil-b cyclodextrin complexes
TL;DR: In this paper, the dissolution of Olmesartan medoxomil from all the prepared complexes was carried out to determine the most appropriate ratio that can be used for further development like tablet formulation for oral delivery.
Dissertation
Design Development and in Vitro Characterization of Glibenclamide Liquisolid Tablet
TL;DR: In this article, the authors used propylene glycol as the non-volatile liquid vehicle to improve the solubility and dissolution characteristics of Glibenclamide using liquisolid technology.
Journal ArticleDOI
Delivery of curcumin in a carboxymethyl cellulose and hydroxypropyl methyl cellulose carrier: Physicochemical properties and biological activity.
TL;DR: In this article , the authors showed that the surface morphology of Curcumin solid dispersions changed from needle-like to sheet-like as observed by scanning electron microscopy, which was positively correlated with the amount of CMC.
Book ChapterDOI
Chapter 33. Pharmaceutics and Biopharmaceutics
TL;DR: In this article, the effect of physicochemical parameters on drug absorption was discussed, such as solubility, particle size, diffusional characteristics, availability, and rate of dissolution of the drug.