Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man.
Keiji Sekiguchi,Noboru Obi +1 more
TLDR
In this paper, it was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of the drug in water, which can be used to adjust the therapeutic effect of medical compounds.Abstract:
1) Sulfathiazole forms eutectic mixtures with urea, l-ascorbic acid, acetamide, nicotinic acid, nicotinamide, or succinimide. It was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of sulfathiazole in water. 2) Sulfathiazole in a eutectic mixture with urea shows higher absorption and excretion after oral administration than ordinary sulfathiazole. 3) Since urea does not possess solubilizing action on sulfathiazole and also it does not enhance absorption of the drug physiologically, the accelerated absorption or excretion must be attributed to the physical state of sulfathiazole in its eutectic mixture with easily soluble compound, such as urea. 4) It is assumed that this new form of preparation will give a means of adjusting therapeutic effect of medical compounds.read more
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Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs.
TL;DR: Critical aspects and recent advances in formulation, preparation and characterization of solid dispersions as well as in-depth pharmaceutical solutions to overcome some problems and issues that limit the development and marketability of solid dispersion products are reviewed.
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Drug Delivery Strategies for Poorly Water-Soluble Drugs
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TL;DR: The emerging formulation designs for delivering of poorly water-soluble drugs, including the massive use of surface-active excipients for solubilisation, are addressed.
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Fundamental aspects of solid dispersion technology for poorly soluble drugs.
Yanbin Huang,Wei-Guo Dai +1 more
TL;DR: The current understanding of solid dispersions both in the solid state and in dissolution is summarized, emphasizing the fundamental aspects of this important technology.
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Review: physical chemistry of solid dispersions
TL;DR: Thorough understanding of the physical chemistry and stability of glass solutions as they form supersaturated solutions, and during their shelf life will elicit conscious evaluation of carrier properties and eventually facilitate rational excipient selection.
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Drug-polymer solubility and miscibility: Stability consideration and practical challenges in amorphous solid dispersion development.
TL;DR: This commentary attempts to discuss the concepts and implications of the drug-polymer solubility and miscibility on the stabilization of solid dispersions, review recent literatures, and propose some practical strategies for the evaluation and development of such systems utilizing a working diagram.