Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man.
Keiji Sekiguchi,Noboru Obi +1 more
Reads0
Chats0
TLDR
In this paper, it was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of the drug in water, which can be used to adjust the therapeutic effect of medical compounds.Abstract:
1) Sulfathiazole forms eutectic mixtures with urea, l-ascorbic acid, acetamide, nicotinic acid, nicotinamide, or succinimide. It was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of sulfathiazole in water. 2) Sulfathiazole in a eutectic mixture with urea shows higher absorption and excretion after oral administration than ordinary sulfathiazole. 3) Since urea does not possess solubilizing action on sulfathiazole and also it does not enhance absorption of the drug physiologically, the accelerated absorption or excretion must be attributed to the physical state of sulfathiazole in its eutectic mixture with easily soluble compound, such as urea. 4) It is assumed that this new form of preparation will give a means of adjusting therapeutic effect of medical compounds.read more
Citations
More filters
Book ChapterDOI
Crystal Growth of Pharmaceuticals from Melt
J.S. Redinha,A.J. Lopes Jesus +1 more
TL;DR: Brittain et al. as discussed by the authors proposed a method for the preparation of crystalline powders and single crystals from solutions by decreasing temperature, solvent evaporation or by the diffusion of a much poorer solvent in solution.
Journal ArticleDOI
Microencapsulation by solvent evaporation method of bcs class 4 drugs for bioavailability enhancement
TL;DR: In this paper, solvent evaporation process is used for size reduction with enclosing polymer coat on active pharmaceutical ingredient, which showed significant rise in bioavailability of drug than pure API.
Journal ArticleDOI
Fast-Dissolving and High-Drug-Loaded, Fatty Acid–Based Self-Emulsifying Solid Dispersions of Diacerein
TL;DR: The utilization of self-emulsifying excipient and surfactant in PEG 6000–based SDs could be a useful tool to enhance the dissolution and bioavailability of diacerein by forming solubilizing and microemulsification systems with high drug content.
Journal ArticleDOI
Solid Dispersion of Nateglinide in Polyoxy Ethylene-Polyoxy Propylene Block Copolymer: in vitro and in vivo Evaluation
TL;DR: The study indicated poloxamer 188 was suitable carrier and melting technique was suitable method for improvement of dissolution and bioavailability of nateglinide.
Journal ArticleDOI
Influence of solvent mixtures on HPMCAS-celecoxib microparticles prepared by electrospraying.
Adam Bohr,Yingya Wang,Moritz Beck-Broichsitter,Moritz Beck-Broichsitter,Mingshi Yang,Mingshi Yang +5 more
TL;DR: It is demonstrated that electrospraying can be used to produce microparticles with tailored properties for pharmaceutical application by adjusting solvent selection.