Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man.
Keiji Sekiguchi,Noboru Obi +1 more
Reads0
Chats0
TLDR
In this paper, it was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of the drug in water, which can be used to adjust the therapeutic effect of medical compounds.Abstract:
1) Sulfathiazole forms eutectic mixtures with urea, l-ascorbic acid, acetamide, nicotinic acid, nicotinamide, or succinimide. It was observed that a eutectic mixture of sulfathiazole and urea produces a microcrystalline suspension of sulfathiazole in water. 2) Sulfathiazole in a eutectic mixture with urea shows higher absorption and excretion after oral administration than ordinary sulfathiazole. 3) Since urea does not possess solubilizing action on sulfathiazole and also it does not enhance absorption of the drug physiologically, the accelerated absorption or excretion must be attributed to the physical state of sulfathiazole in its eutectic mixture with easily soluble compound, such as urea. 4) It is assumed that this new form of preparation will give a means of adjusting therapeutic effect of medical compounds.read more
Citations
More filters
Journal ArticleDOI
Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer based controlled release tablets of aceclofenac to simultaneously enhance the solubility and bioavailability
TL;DR: In this paper, a new polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer (Soloplus®) was used to enhance the solubility of Aceclofenac.
Dissertation
Dynamics and stabilization mechanisms of amorphous solid dispersions
TL;DR: In this paper, the relationship between anti-plasticization effects and hydrogen bonding was investigated in amorphous solid dispersion (ASD) formulations with ibuprofen and felodipine using dielectric spectroscopy, differential scanning calorimetry and FTIR spectrograms.
Formulation and evaluation of clofazimine coevaporates.
TL;DR: In this paper, a solid-dispersion technique was used to improve the aqueous dissolution of CLF using solid dispersal technique, which in turn was also expected to enhance its bioavailability.
OtherDOI
Physicochemical Characterization and Oral Dosage Form Selection Based on the Biopharmaceutics Classification System
TL;DR: The end result of considering physicochemical properties is to reduce the risk of failure by facilitating the identification of appropriate dosage form design options and, at the same time, allow discovery chemists to maximize chances of identifying commercially viable leads.
Journal ArticleDOI
Design, formulation and evaluation of celecoxib solid dispersions prepared by the solvent- evaporation technique
TL;DR: In this paper, solid dispersions of poorly water-soluble Celecoxib were prepared with different polymers or carriers such as Hydroxy Propyl Beta Cyclodextrin, polyvinylpyrrolidone (PVP K30), and Urea.