Journal ArticleDOI
Studies on the anticlastogenic effect of turmeric and curcumin on cyclophosphamide and mitomycin C in vivo.
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TLDR
Although curcumin is reported to be the active chemopreventive principle in turmeric effective against a number of potential carcinogens in several experimental systems, it was virtually ineffective against the clastogenicity of CP or MMC at the doses tested.About:
This article is published in Food and Chemical Toxicology.The article was published on 1998-01-01. It has received 32 citations till now. The article focuses on the topics: Curcumin & Chromosome aberration.read more
Citations
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Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action
TL;DR: The most detailed studies using curcumin include anti-inflammatory, antioxidant, anticarcinogenic, antiviral, and antiinfectious activities as discussed by the authors, and wound healing and detoxifying properties have also received considerable attention.
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Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests.
David Kirkland,Peter Kasper,Hans Jörg Martus,Lutz Müller,Jan van Benthem,Federica Madia,Raffaella Corvi +6 more
TL;DR: Three recommended lists of chemicals that would be appropriate to evaluate the sensitivity and specificity of new/modified mammalian cell genotoxicity tests are updated and how these should be used for any test evaluation program is described.
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Effects of the antioxidants curcumin and vitamin C on cisplatin-induced clastogenesis in Wistar rat bone marrow cells
Lusânia Maria Greggi Antunes,Maria Cristina Picinato Medeiros de Araújo,Joana D'Arc Castania Darin,Maria de Lourdes Pires Bianchi +3 more
TL;DR: Under the present experimental conditions, CMN could prevent cisplatin-induced clastogenesis by acting as a free radical scavenger and the combination between antioxidants would not be effective in protecting against cisplatin-induced chromosomal damage in animals sacrificed 24 h after cisPlatin treatment.
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Antimutagenic properties of bell and black peppers.
TL;DR: The results showed that bell pepper was effective in reducing the mutational events induced by EC and MMS and black pepper was only effective against EC.
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Potentiation by turmeric and curcumin of gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells.
TL;DR: The results clearly indicate the exacerbated effect of turmeric and curcumin on radiation-induced clastogenicity, suggesting that these antioxidants are also potentiating agents depending on the experimental conditions.
References
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Mutagenicity testing of some approved food additives with the Salmonella/microsome assay.
A. M. Bonin,R. S. U. Baker +1 more
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Testing of some permitted food colours for the induction of gene conversion in diploid yeast.
TL;DR: 12 permitted food colours in use were screened for geno-toxicity and did not cause any increase in mitotic gene conversion in diploid yeast BZ 34.
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Mutagenic potential of the condiments, ginger and turmeric.
TL;DR: Extracts of fresh rhizomes of Zingiber officinale (ginger) and Curcuma longa (turmeric) are radiomimetic and may be mutagenic and the predominant type of aberration was chromosome breakage.
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Genotoxicity tests as predictors of carcinogens: An analysis
TL;DR: Instead of relying primarily on short-term in vitro genotoxicity tests to predict carcinogenic activity, these tests should be used in a manner that emphasizes the accurate determination of mutagenicity or clastogenicity.
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Phenethyl isotiocyanate modulates clastogenicity of mitomycin C and cyclophosphamide in vivo
TL;DR: Although PEITC is reported to be effective against N-nitrosamine-induced tumorigenesis by preventing metabolic activation and by blocking the reactive species formed, it is virtually ineffective against the clastogenicity of cyclophosphamide.