Journal ArticleDOI
Studies on the anticlastogenic effect of turmeric and curcumin on cyclophosphamide and mitomycin C in vivo.
TLDR
Although curcumin is reported to be the active chemopreventive principle in turmeric effective against a number of potential carcinogens in several experimental systems, it was virtually ineffective against the clastogenicity of CP or MMC at the doses tested.About:
This article is published in Food and Chemical Toxicology.The article was published on 1998-01-01. It has received 32 citations till now. The article focuses on the topics: Curcumin & Chromosome aberration.read more
Citations
More filters
Journal ArticleDOI
Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action
TL;DR: The most detailed studies using curcumin include anti-inflammatory, antioxidant, anticarcinogenic, antiviral, and antiinfectious activities as discussed by the authors, and wound healing and detoxifying properties have also received considerable attention.
Journal ArticleDOI
Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests.
David Kirkland,Peter Kasper,Hans Jörg Martus,Lutz Müller,Jan van Benthem,Federica Madia,Raffaella Corvi +6 more
TL;DR: Three recommended lists of chemicals that would be appropriate to evaluate the sensitivity and specificity of new/modified mammalian cell genotoxicity tests are updated and how these should be used for any test evaluation program is described.
Journal ArticleDOI
Effects of the antioxidants curcumin and vitamin C on cisplatin-induced clastogenesis in Wistar rat bone marrow cells
Lusânia Maria Greggi Antunes,Maria Cristina Picinato Medeiros de Araújo,Joana D'Arc Castania Darin,Maria de Lourdes Pires Bianchi +3 more
TL;DR: Under the present experimental conditions, CMN could prevent cisplatin-induced clastogenesis by acting as a free radical scavenger and the combination between antioxidants would not be effective in protecting against cisplatin-induced chromosomal damage in animals sacrificed 24 h after cisPlatin treatment.
Journal ArticleDOI
Antimutagenic properties of bell and black peppers.
TL;DR: The results showed that bell pepper was effective in reducing the mutational events induced by EC and MMS and black pepper was only effective against EC.
Journal ArticleDOI
Potentiation by turmeric and curcumin of gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells.
TL;DR: The results clearly indicate the exacerbated effect of turmeric and curcumin on radiation-induced clastogenicity, suggesting that these antioxidants are also potentiating agents depending on the experimental conditions.
References
More filters
Journal ArticleDOI
Potential anticancer activity of turmeric (Curcuma longa)
TL;DR: Initial experiments indicated that turmeric extract and curcumin reduced the development of animal tumours.
Journal Article
Inhibitory Effects of Dietary Curcumin on Forestomach, Duodenal, and Colon Carcinogenesis in Mice
TL;DR: Results indicate that not only did curcumin inhibit the number of tumors per mouse and the percentage of mice with tumors but it also reduced tumor size.
Journal ArticleDOI
A molecular mechanism of mitomycin action: linking of complementary dna strands.
V. N. Iyer,Waclaw Szybalski +1 more
TL;DR: The absence of a pre heating effect in PRi is to be contrasted with the marked preheating effect observed by Horiuchi et al., J. Mol.
Journal ArticleDOI
Turmeric — chemistry, technology, and quality
TL;DR: This review critically appraises the existing knowledge on the chemistry of the functionally important constituents, the processing of the spice into wholes, powder, and oleoresins, and the objective methods and standards available for evaluation of quality.
Journal ArticleDOI
NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals
TL;DR: It is postulate that the formation of the "site-specific free radical/ intermediate is central to the cytotoxic action of these antibiotics.