Study of the interaction of the palmatine alkaloid with hybrid G-quadruplex/duplex and i-motif/duplex DNA structures.
TLDR
In this paper, the interaction of the palmatine alkaloid with several sequences forming different G4s, iMs, and hybrid structures has been studied by means of spectroscopic and separation techniques, as well as multivariate data analysis methods.About:
This article is published in Biophysical Chemistry.The article was published on 2022-02-01 and is currently open access. It has received 2 citations till now. The article focuses on the topics: Chemistry & G-quadruplex.read more
Citations
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Nanopore Liberates G-Quadruplexes from Biochemical Buffers for Accurate Mass Spectrometric Examination.
TL;DR: In this paper , a nanopore ion emitter was used to extract G-quadruplexes (G4s) from aqueous buffers for mass spectrometric examination.
Journal ArticleDOI
Exploring the stabilizing effect on the i-motif of neighboring structural motifs and drugs.
Judit Garzón Rodríguez,Arnau Domínguez,Anna Aviñó,Gigliola Borgonovo,Ramon Eritja,Stefania Mazzini,Raimundo Gargallo +6 more
TL;DR: In this article , the relative effect of DNA ligands on the stabilization of the i-motif has been studied and the results showed that the duplex is the moiety that is responsible of the stabilization at neutral pH.
References
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Circular dichroism and conformational polymorphism of DNA
TL;DR: Here the authors review studies that provided important information about conformational properties of DNA using circular dichroic (CD) spectroscopy, which significantly participated in all basic conformational findings on DNA.
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NUPACK: Analysis and design of nucleic acid systems
Joseph N. Zadeh,Conrad Steenberg,Justin S. Bois,Brian R. Wolfe,Marshall B. Pierce,Asif R. Khan,Robert M. Dirks,Niles A. Pierce +7 more
TL;DR: The Nucleic Acid Package (NUPACK) is a growing software suite for the analysis and design of nucleic acid systems and algorithms are formulated in terms ofucleic acid secondary structure.
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TL;DR: OligoCalc incorporates three common methods for calculating oligonucleotide-melting temperatures, including a nearest-neighbor thermodynamic model for melting temperature.
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I-motif DNA structures are formed in the nuclei of human cells
Mahdi Zeraati,Mahdi Zeraati,David B. Langley,Peter R. Schofield,Aaron L. Moye,Romain Rouet,William E. Hughes,William E. Hughes,Tracy M. Bryan,Marcel E. Dinger,Marcel E. Dinger,Daniel Christ,Daniel Christ +12 more
TL;DR: The generation and characterization of an antibody fragment (iMab) is reported that recognizes i-motif structures with high selectivity and affinity, enabling the detection of i- Motifs in the nuclei of human cells and providing evidence that i-Motif structures are formed in regulatory regions of the human genome, including promoters and telomeric regions.
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A spectroscopic study on the interactions of porphyrin with G-quadruplex DNAs.
TL;DR: New insights are provided into the effect of H(2)TMPyP4 binding on the structures of G- quadruplexes and Raman spectroscopy is demonstrated to be an ideal method for examining the interaction between drugs and G-quadruplexe.