Journal ArticleDOI
Sulfonylhydrazones: Design, synthesis and investigation of ectonucleotidase (ALP & e5'NT) inhibition activities.
Hafiza Amna Younus,Abdul Hameed,Abid Mahmood,Muhammad Siraj Khan,Muhammad Saeed,Farwa Batool,Asnuzilawati Asari,Habsah Mohamad,Julie Pelletier,Jean Sévigny,Jamshed Iqbal,Mariya al-Rashida +11 more
Reads0
Chats0
TLDR
The potent compounds 5a, 7, and 9d against different ectonucleotidases (h-ecto 5'-NT, h-TNAP, h -IAP) could potentially serve as lead for the development of new therapeutic agents.About:
This article is published in Bioorganic Chemistry.The article was published on 2020-07-01. It has received 10 citations till now.read more
Citations
More filters
Journal ArticleDOI
The bioactivity of benzenesulfonyl hydrazones: A short review.
TL;DR: The synthesis and biological activity evaluation of benzenesulfonyl hydrazones is quite frequently encountered in scientific literature as discussed by the authors, which is very interesting due to the wide spectrum of potential applications in the field of medicinal chemistry.
Journal ArticleDOI
2-Benzylidenebenzofuran-3(2H)-ones as a new class of alkaline phosphatase inhibitors: synthesis, SAR analysis, enzyme inhibitory kinetics and computational studies
Journal ArticleDOI
Development of New Antimycobacterial Sulfonyl Hydrazones and 4-Methyl-1,2,3-thiadiazole-Based Hydrazone Derivatives
Violina T. Angelova,Tania Pencheva,Nikolay Vassilev,Elena K.-Yovkova,Rositsa Mihaylova,Boris Petrov,Violeta Valcheva +6 more
TL;DR: The 4-methyl-1,2,3-thiadiazole-based hydrazone derivatives and sulfonyl hydrazones proved to be new classes of lead compounds having the potential of novel candidate antituberculosis drugs.
Journal ArticleDOI
Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors.
Abida Ashraf,Zahid Shafiq,Muhammad Siraj Khan Jadoon,Muhammad Tahir,Julie Pelletier,Jean Sévigny,Muhammad Yaqub,Jamshed Iqbal +7 more
TL;DR: An efficient, environment friendly route for the synthesis of non-nucleotide based small molecules is reported, i.e., substituted spirooxindole derivatives 9a-9l and in silico studies were carried out to assess binding interactions of potent compounds within enzyme active sites and demonstrated excellent correlation with the experimental findings.
Journal ArticleDOI
Targeting ecto-5'-nucleotidase: A comprehensive review into small molecule inhibitors and expression modulators.
Gustavo Machado das Neves,Luciano Porto Kagami,Ana Maria Oliveira Battastini,Fabrício Figueiró,Vera Lucia Eifler-Lima +4 more
TL;DR: In this article , the authors highlight important biochemical and structural features of ecto-5'NT, highlight its expression profile in normal and cancer cell lines detailing compounds which may act as expression regulators and to review the several classes of ectoe-5'-NT inhibitors developed in the past 12 years, in order to build a general structure-activity relationship model to guide further compound design.
References
More filters
Journal ArticleDOI
The role of alkaline phosphatase in mineralization
TL;DR: The mechanism with which this enzyme carries out its function is not complete and it is appropriate to review the current status of this important enzyme.
Journal ArticleDOI
Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO(2) capture.
TL;DR: Novel drug design strategies have been reported principally based on the tail approach for obtaining all these types of CAIs, which exploit more external binding regions within the enzyme active site (in addition to coordination to the metal ion), leading thus to isoformselective compounds.
Journal ArticleDOI
Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides.
TL;DR: It has been proposed that the recently observed beneficial effect of indapamide for the treatment of patients with hypertension and type 2 diabetes might be due to its potent inhibition of CA isoforms present in kidneys and blood vessels, which would explain both the blood pressure lowering effects as well as organ-protective activity of the drug.
Journal ArticleDOI
Novel Inhibitors of Alkaline Phosphatase Suppress Vascular Smooth Muscle Cell Calcification
Sonoko Narisawa,Dympna Harmey,Manisha C. Yadav,W. Charles O'Neill,Marc Hoylaerts,José Luis Millán +5 more
TL;DR: Three novel inhibitors of the physiological pyrophosphatase activity of alkaline phosphatase are reported and it is shown that these compounds are capable of reducing calcification in two models of vascular calcification.
Journal ArticleDOI
Ecto-5'-nucleotidase: Structure function relationships.
TL;DR: The currently available structural information on ecto-5’NT is reviewed in relation to the catalytic properties and enzyme function.