Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
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The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
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Role of oxygen free radicals in carcinogenesis and brain ischemia.
TL;DR: Evidence is presented that a new class of free radical blocking agents, nitrone spin‐traps, may help not only to clarify if free radical events are involved, but may help prevent the development of injury in certain pathological conditions.
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Catalytic metals, ascorbate and free radicals: combinations to avoid.
TL;DR: This presentation discusses the role of catalytic metals in free radical-mediated oxidations, ascorbate as both a pro-oxidant and an antioxidant, use of asCorbate to determine adventitious catalytic metal concentrations, and uses of ascorBate radical as a marker of oxidative stress.
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Superoxide-dependent production of hydroxyl radical catalyzed by iron-EDTA complex.
TL;DR: Reaction 1 was the simplest explanation accommodating all the observed facts, and the reaction had been proposed many years earlier by Haber and Weiss during their studies of the catalytic decomposition of hydrogen peroxide by iron salts.
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Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
TL;DR: Production of ROS at mitochondria integrates cellular energy state, metabolite concentrations, and other upstream signaling events and has important implications in cellular stress signaling, maintenance of stem cell populations, cellular survival, and oncogenic transformation.
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Oxidative processes and antioxidative defense mechanisms in the aging brain.
TL;DR: A newly discovered, potentially highly important antioxidant in the brain is the indole melatonin, which is more effective than glutathione in scavenging the highly toxic hydroxyl radical and also more efficient than vitamin E in neutralizing the peroxyl radical.
References
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The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
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The microestimation of succinate and the extinction coefficient of cytochrome c.
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The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
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The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
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Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.