Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
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The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
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Radiocontrast medium-induced declines in renal function: a role for oxygen free radicals.
TL;DR: It is concluded that intrarenal injection of RCM results in increased production ofOFR, and inhibition of OFR production by allopurinol and increased OFR removal by SOD attenuates the effects ofRCM on declines in GFR.
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Progress towards biocompatible intracortical microelectrodes for neural interfacing applications
Mehdi Jorfi,John L. Skousen,John L. Skousen,Christoph Weder,Jeffrey R. Capadona,Jeffrey R. Capadona +5 more
TL;DR: This review provides a comprehensive reflection on the current understanding of the key failure modes that may impact intracortical microelectrode performance and presents the vision on the future directions of materials-based treatments for neural interfacing.
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Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures.
TL;DR: This review focuses on the emerging role of oxidative stress and mitochondrial dysfunction both as a consequence and as a cause of epileptic seizures.
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Protective systems against active oxygen species in spinach: response to cold acclimation in excess light.
TL;DR: Cold acclimation led to several metabolic and biochemical changes that apparently include improved protection of the photosynthetic apparatus against active oxygen species and possible relevance for plant resistance to photoinhibition at chilling temperatures.
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Reactive oxygen species generation by human spermatozoa is induced by exogenous NADPH and inhibited by the flavoprotein inhibitors diphenylene iodonium and quinacrine
R. John Aitken,Helen M. Fisher,Norma Fulton,Emilio Gomez,Wendy Knox,Beverley Lewis,Stewart Irvine +6 more
TL;DR: The results indicate that NAD(P)H can serve as an electron donor for superoxide generation by human spermatozoa and present a simple strategy for the production of motile populations of free radical generating cells with which to study the significance of these molecules in the control of normal and pathological sperm function.
References
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The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
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The microestimation of succinate and the extinction coefficient of cytochrome c.
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The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
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The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
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Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.