Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
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The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
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Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism?
TL;DR: It is suggested that a low rate of mitochondrial ROS generation extends lifespan both in long‐lived and in caloric‐restricted animals by determining the rate of oxidative attack and accumulation of somatic mutations in mitochondrial DNA.
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Epithelial–Mesenchymal Transition: From Molecular Mechanisms, Redox Regulation to Implications in Human Health and Disease
Stefania Cannito,Erica Novo,Lorenzo Valfrè di Bonzo,Chiara Busletta,Sebastiano Colombatto,Maurizio Parola +5 more
TL;DR: This review offers a comprehensive introduction to describe major relevant features of EMT, followed by sections dedicated on those signaling mechanisms that are known to regulate or affect the process, including the recently proposed role for oxidative stress and reactive oxygen species (ROS).
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Changes in the Activities of Anti-Oxidant Enzymes during Exposure of Intact Wheat Leaves to Strong Visible Light at Different Temperatures in the Presence of Protein Synthesis Inhibitors.
TL;DR: The induction of the enzymes except for catalase and increase in the levels of ascorbate and total carotenoids in response to the stress conditions indicate that they play an important role in the protection of higher plants from the damaging effects of toxic active species.
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Superoxide and the production of oxidative DNA damage.
TL;DR: Experiments with iron transport mutants confirmed that increases in free-iron concentration have the effect of accelerating DNA oxidation, suggesting that O2- may be genotoxic only in doses that exceed those found in SOD-proficient cells, and in those limited circumstances it may promote DNA damage by increasing the amount of DNA-bound iron.
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The oxygen free radical system: A fundamental mechanism in the production of myocardial necrosis
TL;DR: The discovery of the enzyme superoxide dismutase that catalyzed the production of hydrogen peroxide from superoxide anion defined the new field of oxygen metabolism in biologic systems and a potential role of oxidation/reduction reactions in both physiologic and pathologic conditions.
References
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The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
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The microestimation of succinate and the extinction coefficient of cytochrome c.
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The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
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The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
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Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.