Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
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The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
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The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.
Richard B. Johnston,Bernard B. Keele,Hara P. Misra,J E Lehmeyer,L S Webb,R L Baehner,K.V. Rajagopalan +6 more
TL;DR: It would seem clear from these and other studies that the granulo cyte elaborates O2- as a concomitant of the respiratory burst that occurs with phagocytosis, and a requirement for .OH in thephagocytic bactericidal event might explain the apparent requirement for both O1- and H2O2 for such activity.
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Ischemic injury in the cat small intestine: Role of superoxide radicals
Dale A. Parks,Dale A. Parks,Gregory B. Bulkley,Gregory B. Bulkley,D. Neil Granger,D. Neil Granger,Stanley R. Hamilton,Stanley R. Hamilton,Joe M. McCord,Joe M. McCord +9 more
TL;DR: The results of this study suggest that superoxide radicals are involved in the pathogenesis of ischemic mucosal lesions and that the enzyme xanthine oxidase is the source ofsuperoxide radicals in the isChemic small bowel.
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Antioxidant systems and o2.?/h2o2 production in the apoplast of pea leaves. its relation with salt-induced necrotic lesions in minor veins
TL;DR: The results suggest a strong interaction between both cell compartments in the control of the apoplastic ASC content in pea leaves, but this anti-oxidative response does not seem to be sufficient to remove the harmful effects of high salinity.
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Regulation of superoxide dismutase genes: implications in disease.
Lu Miao,Daret K. St. Clair +1 more
TL;DR: Evaluation of nucleotide sequences reveals that regulatory elements of the sod2 gene reside in both the noncoding and the coding region, and changes associated with sod2 lead to alterations in expression levels as well as protein function.
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The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling
TL;DR: The in vitro ROS‐producing capacity of several mitochondrial sites is compared in the metabolic context and the role of mitochondria in ROS‐dependent intracellular signaling is discussed.
References
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The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
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The microestimation of succinate and the extinction coefficient of cytochrome c.
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The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
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The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
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Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.