Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
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The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
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Chemical characterization and antioxidant activities of oligomeric and polymeric procyanidin fractions from grape seeds.
TL;DR: The results indicate that the antioxidant activities of grape seed procyanidins are positively related to their degree of polymerization, suggesting that grape seed ProcyanIDins might be of interest to be used as alternative antioxidants.
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Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis: Decreased stability of the apo state
TL;DR: Compared the unfolding behavior of five ALS-associated mutants with distinct structural characteristics, organism-level pathology may be directly related to the properties of the immature state of a protein rather than to those of the native species.
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Characterization of drugs as antioxidant prophylactics
TL;DR: The current evidence to support the notion that drugs for a particular therapeutic category might possess useful antioxidant capacity hence minimising tissue injury due to free radicals is examined.
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The toxicology of molecular oxygen.
DiGuiseppi J,Fridovich I +1 more
TL;DR: This work considers the threat posed by oxygen and the defenses which make aerobic life possible and the compounds which increase the conversion of oxygen to its more reactive derivatives.
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Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis.
TL;DR: It is shown that apoSOD1 without disulfide is the most facile state for formation of amyloid-like fibrillar aggregates and proposed that facilitation of post-translational modifications is a promising strategy to reduce SOD1 aggregation in the cell.
References
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The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
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The microestimation of succinate and the extinction coefficient of cytochrome c.
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The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
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The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
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Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.