Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
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The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
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The formation of free radicals and the consequences of their reactions in vivo.
TL;DR: Mechanisms for the initiation of free radical reactions in vivo are reviewed, including ozone and 1O2 reactions, radiation, one‐electron transfer processes, and enzymatic reactions.
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Superoxide and singlet oxygen in milk lipid peroxidation
TL;DR: In this article, the authors investigated the extent to which the excited state molecular oxygen species, singlet oxygen 1 O 2, participates in milk lipid oxidation and found that it is the immediate source of the hydroperoxides that initiate lipid oxidation catalyzed by three agents.
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Antioxidant status in persons with and without senile cataract.
TL;DR: Results suggest that subjects with high levels of at least two of the three vitamins are at reduced risk of cataract relative to subjects with low levels of one or more of these vitamins.
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Oxidative stress, redox regulation and diseases of cellular differentiation.
TL;DR: Current understanding of how ROS arise, facilitate cell signaling, cause toxicities and disease related to abnormal cell differentiation and those sulfur based pathways that provide nucleophilicity to offset these effects are discussed.
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Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver.
Debra L. Laskin,Anne M. Pilaro +1 more
TL;DR: In this article, the authors compared the morphologic and functional characteristics of macrophages obtained from liver livers of treated and untreated rats with those of resident Kupffer cells from untreated control animals and found that macrophage populations were chemotactic to a number of stimuli including the complement fragment, C5a, and synthetic collagenous peptides related to tissue breakdown products.
References
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The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
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The microestimation of succinate and the extinction coefficient of cytochrome c.
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The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
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The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
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Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.