Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
Reads0
Chats0
TLDR
The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
Citations
More filters
Journal ArticleDOI
The Role of Oxygen-free Radicals in Ischemic Tissue Injury in Island Skin Flaps
TL;DR: Treatment with superoxide dismutase, a scavenger of superoxide radicals, prior to and immediately following the onset of reperfusion, significantly enhanced island flap survival, consistent with the hypothesis that oxygen free radicals generated at the time of reperFusion following a period of ischemia contribute significantly to the ultimate damage caused by ischemic injury.
Journal ArticleDOI
Antioxidant and free radical scavenging activities of wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) in Taiwan
Shu-Jing Wu,Lean-Teik Ng +1 more
TL;DR: Results showed that BM extracts possess potent antioxidant and free radical scavenging activities, which could have contributed, at least partly, to the therapeutic benefits of the certain traditional claims of wild BM.
Journal Article
Free radicals: their history and current status in aging and disease
TL;DR: There are extensive global basic research efforts to define more clearly the role of free radicals and oxidative stress in aging and various diseases as well as in numerous human diseases/disorders where they have either a primary or secondary role.
Journal ArticleDOI
The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron
TL;DR: It is proposed that a ferrous-dioxygen-ferric chelate complex may be the initiating species in lipid peroxidation, and studies with oxy-radical scavengers and catalase suggest that O2-., H2O2, or the .OH are not involved in the initiation reactions.
Journal ArticleDOI
Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions.
TL;DR: Modification of DNA bases in mammalian chromatin upon treatment with hydrogen peroxide in the presence of ferric and cupric ions was studied, indicating a possible site-specific formation of hydroxyl radical when metal ions are bound to chromatin.
References
More filters
Journal ArticleDOI
The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
Journal ArticleDOI
The microestimation of succinate and the extinction coefficient of cytochrome c.
Journal ArticleDOI
The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
Journal ArticleDOI
The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
Journal ArticleDOI
Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.