Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
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The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
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SOD mimetics are coming of age.
TL;DR: Tissue injury and inflammation form the basis of many disease pathologies, including ischaemia and reperfusion injuries, radiation injury, hyperoxic lung damage and atherosclerosis, which provides a unique opportunity to manipulate numerous disease states with an agent that removes superoxide anions.
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Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats.
TL;DR: It is established that intratracheal administration of rhKGF stimulated alveolar type II cell proliferation in vivo and reduced hyperoxia-induced lung injury in rats and directed delivery of KGF to the lungs may provide a therapeutic strategy to preserve or restore theAlveolar epithelium during exposure tohyperoxia or other injurious agents.
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On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies
Carolina Muscoli,Salvatore Cuzzocrea,Dennis P. Riley,Jay L. Zweier,Christoph Thiemermann,Zhi Qiang Wang,Daniela Salvemini +6 more
TL;DR: This review will discuss the advances made using various superoxide dismutase mimetics that led to the proposal that superoxide (and/or the product of its interaction with nitric oxide, peroxynitrite) is an important mediator of inflammation, and to the conclusion that super poisoning mimetics can be utilized as therapeutic agents in diseases of various etiologies.
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The microbicidal mechanisms of human neutrophils and eosinophils.
Richard K. Root,Myron S. Cohen +1 more
TL;DR: The objective was to establish a chronology of events leading to and following the initiation of Cellular Microbicidal Activity, as well as to investigate the relationship between O2formation and other events.
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Superoxide production by phagocytic leukocytes.
D B Drath,M L Karnovsky +1 more
TL;DR: Of the mouse monocytic cells studied, alveolar macrophages released the largest amounts of superoxide during phagocytosis, followed by normal peritoneal macrophage, and in the guinea pig, polymorphonuclear leukocytes and casein-elicited Macrophages were shown to release superoxide whereas alveolars did not.
References
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The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
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The microestimation of succinate and the extinction coefficient of cytochrome c.
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The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
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The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
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Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.