Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
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The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
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Oxygen-derived free radicals promote hepatic injury in the rat*
Michael J. P. Arthur,I.S. Bentley,A.R. Tanner,P.Kowalski Saunders,G.H. Millward-Sadler,Ralph Wright +5 more
TL;DR: Results indicate that oxygen-derived free radicals may play an important role in the pathogenesis of hepatic injury in the rat, and warn against underestimating the role of superoxide dismutase in this process.
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Lysosomal and antioxidant responses to metals in the Antarctic scallop Adamussium colbecki
TL;DR: The results obtained from the transplantation experiment indicated only very limited effects on scallops translocated near the effluents of the Italian Base suggesting that the biological impact of the Base should not have major deleterious consequences on benthic marine communities.
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Inhibition of collagen gelation by action of the superoxide radical.
Robert A. Greenwald,Wai W. Moy +1 more
TL;DR: Since inhibition of collagen gelation reflects alteration of collagen biochemistry, and/or collagen degradation, it is suggested that the action of free radicals produced in vivo by leukocytes may adversely affect the structural or functional integrity of cartilage and adjacent joint structures.
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Contractions to oxygen-derived free radicals are augmented in aorta of the spontaneously hypertensive rat.
TL;DR: The lack of effect of the scavengers on endothelium-dependent contractions to acetylcholine in aortas from the SHR were not affected by deferoxamine or superoxide dismutase plus catalase, which suggest that hydroxyl radicals cause contractions in the rat aorta, which are dependent on extracellular calcium and mediated by activation of the cyclooxygenase in the vascular smooth muscle.
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Metabolism of Oxygen Derivatives in Down's Syndrome*
TL;DR: Observations as well as many features of this disease are consistent with increased oxidative damage in trisomy 21 cells, and the consideration of some aspects of the properties of CuZn SOD suggests the possibility of a role for the excess enzyme in this aspect of the pathogeny of tr isomy 21.
References
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The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
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The microestimation of succinate and the extinction coefficient of cytochrome c.
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The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
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The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
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Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.