Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
Reads0
Chats0
TLDR
The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-11-25 and is currently open access. It has received 12468 citations till now. The article focuses on the topics: Copper chaperone for superoxide dismutase & Superoxide reductase.read more
Citations
More filters
Journal ArticleDOI
Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy and beyond
Fatma Vatansever,Wanessa C.M.A. de Melo,Wanessa C.M.A. de Melo,Pinar Avci,Pinar Avci,Daniela Vecchio,Magesh Sadasivam,Magesh Sadasivam,Asheesh Gupta,Asheesh Gupta,Rakkiyappan Chandran,Rakkiyappan Chandran,Mahdi Karimi,Mahdi Karimi,Nivaldo Antonio Parizotto,Rui Yin,Rui Yin,George P. Tegos,Michael R. Hamblin,Michael R. Hamblin +19 more
TL;DR: Antioxidant defenses against ROS in microbial cells and the use of ROS by antimicrobial host defense systems are covered and reactive nitrogen species and related therapeutics, such as acidified nitrite and nitric oxide-releasing nanoparticles are covered.
Journal ArticleDOI
Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis
Martina Wiedau-Pazos,Joy J. Goto,Shahrooz Rabizadeh,Edith Butler Gralla,James A. Roe,Michael K. Lee,Joan Selverstone Valentine,Dale E. Bredesen +7 more
TL;DR: Results suggest that oxidative reactions catalyzed by mutant CuZnSOD enzymes initiate the neuropathologic changes in FALS.
Journal ArticleDOI
Superoxide-dependent formation of hydroxyl radicals in the presence of iron chelates: is it a mechanism for hydroxyl radical production in biochemical systems?
Journal ArticleDOI
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation.
TL;DR: The dysregulation of Nrf2-regulated genes provides a logical explanation for the connections between observable oxidative stress and perhaps 200 human diseases involving these various physiological processes, each reflecting a network involving many gene products.
Journal ArticleDOI
Parkinson's disease: a disorder due to nigral glutathione deficiency?
TL;DR: The hypothesis that loss of nigrostriatal dopaminergic neurons results from a regional GSH deficiency could have important therapeutic implications for the management and prevention of Parkinson's disease.
References
More filters
Journal ArticleDOI
The Reduction of Cytochrome c by Milk Xanthine Oxidase
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The data are consistent with the conclusion that xanthine oxidase generates an unstable reduced form of oxygen, presumably the superoxide anion, and that this radical is the agent which directly reduces cytochrome c and initiates the sulfite-oxygen chain reaction.
Journal ArticleDOI
The microestimation of succinate and the extinction coefficient of cytochrome c.
Journal ArticleDOI
The Preparation and Properties of Deflavo Xanthine Oxidase
TL;DR: The deflavoenzyme is catalytically active in the oxidation of xanthine with acceptors such as ferricyanide and cytochrome c.
Journal ArticleDOI
The mechanism of aerobic oxidase reaction catalyzed by peroxidase.
TL;DR: It has been found that peroxidase catalyzes the formation of free radicals of hydrogen donors in the presence of H 2 O 2, and Compound III is not an active intermediate for dihydroxyfumarate oxidation.
Journal ArticleDOI
Electron-spin-resonance evidence for enzymic reduction of oxygen to a free radical, the superoxide ion.
TL;DR: It is concluded that the species observed is the superoxide ion, O(2) (-), and that the stability of this ion is greatly increased in alkaline solution.