Journal ArticleDOI
Surface chemistry and pore size affect carrier properties of mesoporous silicon microparticles.
Tarja Limnell,Joakim Riikonen,Jarno Salonen,Ann Marie Kaukonen,Leena Laitinen,Jouni Hirvonen,V.-P. Lehto +6 more
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TLDR
In this article, the effect of surface treatment and pore sizes on mesoporous silicon microparticles on their properties as drug carriers was evaluated using a mixture of as-anodized, thermally carbonized (TCPSi), thermally oxidized (TOPSi), annealed TOPSi and thermally hydrocarbonized porous silicon (THCPSi).About:
This article is published in International Journal of Pharmaceutics.The article was published on 2007-10-01. It has received 101 citations till now. The article focuses on the topics: Porous silicon & Microparticle.read more
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Porous silicon in drug delivery devices and materials
TL;DR: The optical properties of photonic structures prepared from porous Si or SiO2 hosts provide a self-reporting feature that can be monitored in vivo.
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The biocompatibility of mesoporous silicates.
TL;DR: In vitro, mesoporous silicates showed a significant degree of toxicity at high concentrations with mesothelial cells, and following subcutaneous injection of silicates in rats, the amount of residual material decreased progressively over 3 months, with good biocompatibility on histology at all time points.
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Biocompatibility of Thermally Hydrocarbonized Porous Silicon Nanoparticles and their Biodistribution in Rats
Luis M. Bimbo,Mirkka Sarparanta,Hélder A. Santos,Anu J. Airaksinen,Ermei Mäkilä,Timo Laaksonen,Leena Peltonen,Vesa-Pekka Lehto,Jouni Hirvonen,Jarno Salonen +9 more
TL;DR: Results show that thermally hydrocarbonized porous silicon (THCPSi) nanoparticles did not induce any significant toxicity, oxidative stress, or inflammatory response in Caco-2 and RAW 264.7 macrophage cells.
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Mesoporous systems for poorly soluble drugs
TL;DR: If mesoporous materials could be employed in the industrial crystallization processes to produce hybrid materials with poorly soluble compounds, and hence to enhance their oral bioavailability, this might open new avenues for the pharmaceutical industry to employ nanotechnology in their processes.
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Fabrication and chemical surface modification of mesoporous silicon for biomedical applications
Jarno Salonen,Vesa-Pekka Lehto +1 more
TL;DR: This review will focus on the fabrication and chemical modifications of porous silicon for biomedical applications, but a wide variety of biomedical applications will be discussed also.
References
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Journal ArticleDOI
Silicon quantum wire array fabrication by electrochemical and chemical dissolution of wafers
TL;DR: In this paper, free standing Si quantum wires can be fabricated without the use of epitaxial deposition or lithography using electrochemical and chemical dissolution steps to define networks of isolated wires out of bulk wafers.
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A New Property of MCM-41: Drug Delivery System
TL;DR: In this paper, a new application of MCM-41 mesoporous materials has been developed, where two kinds of surfactants, C16TAB and C12TAB, have been employed to get different pore sizes.
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What is the true solubility advantage for amorphous pharmaceuticals
Bruno C. Hancock,Michael Parks +1 more
TL;DR: Amorphous pharmaceuticals are markedly more soluble than their crystalline counterparts, however, their experimental solubility advantage is typically less than that predicted from simplethermodynamic considerations.
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Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs.
Jarno Salonen,Leena Laitinen,Ann Marie Kaukonen,Jaani Tuura,Mikko Björkqvist,Teemu Heikkilä,Kalle Vähä-Heikkilä,Jouni Hirvonen,Vesa-Pekka Lehto +8 more
TL;DR: Loading of drugs into TCPSi and TOPSi microparticles showed, that in addition to effects regarding the stability of the particles in the presence of aqueous or organic solvents, surface properties will affect compound affinity towards the particle.
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Ordered Mesoporous Materials in the Context of Drug Delivery Systems and Bone Tissue Engineering
TL;DR: This paper tries to introduce an example of such an interaction, aimed at solving health issues within the world of biomaterials, within the field of drug delivery systems and tissue engineering.