Symbionts and gene drive: two strategies to combat vector-borne disease.
TLDR
In this paper , Bhatt et al. reviewed the latest developments in both symbionts and gene drive-based methods, as well as distinctions and obstacles relating to these promising technologies.About:
This article is published in Trends in Genetics.The article was published on 2022-03-18 and is currently open access. It has received 24 citations till now. The article focuses on the topics: Medicine & Biology.read more
Citations
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Experimental demonstration of tethered gene drive systems for confined population modification or suppression
TL;DR: In this paper , the authors demonstrate the engineering of a tethered drive system in Drosophila , using a regionally confined CRISPR Toxin-Antidote Recessive Embryo (TARE) drive to support modification and suppression homing drives.
Posted ContentDOI
Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models
TL;DR: In this paper , the authors extend the continuous space gene drive framework to include two competing species or predator-prey species pairs and find that the presence of a competing species can greatly facilitate drive-based suppression, even for drives with modest efficiency.
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Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: A modeling study
Jiahe Li,Jackson Champer +1 more
TL;DR: It is found that a drive containing CifA and CifB together create a confined drive with a moderate to high introduction threshold, and when introduced separately, they act as a self-limiting drive.
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Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure
TL;DR: In this article , the authors analyzed experimental data from each of these gene drives to extract their characteristics and performance parameters, and compared these to previous interpretations of their experimental performance, finding that the combined homing/X-shredder drive is actually less effective at population suppression within the context of their individual-based simulation framework.
Journal ArticleDOI
Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure
TL;DR: It is found that the combined homing/X-shredder drive is actually less effective at population suppression within the context of the mosquito population model, and otherwise similar drives based on the nos promoter may prove to be more promising candidates for future development than originally thought.
References
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The global distribution and burden of dengue
Samir Bhatt,Peter W. Gething,Oliver J. Brady,Jane P. Messina,Andrew Farlow,Catherine L. Moyes,John M. Drake,John M. Drake,John S. Brownstein,Anne G. Hoen,Osman Sankoh,Osman Sankoh,Monica F. Myers,Dylan B. George,Thomas Jaenisch,G. R. William Wint,Cameron P. Simmons,Thomas W. Scott,Thomas W. Scott,Jeremy Farrar,Jeremy Farrar,Simon I. Hay,Simon I. Hay +22 more
TL;DR: These new risk maps and infection estimates provide novel insights into the global, regional and national public health burden imposed by dengue and will help to guide improvements in disease control strategies using vaccine, drug and vector control methods, and in their economic evaluation.
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How many species are infected with Wolbachia?--A statistical analysis of current data.
TL;DR: A meta-analysis that estimates percentage of infected species based on data on the distribution of infection levels among species using a beta-binomial model and finds that within species the infection frequency follows a ‘most-or-few’ infection pattern.
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A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
Andrew Hammond,Roberto Galizi,Kyros Kyrou,Alekos Simoni,Carla Siniscalchi,Dimitris Katsanos,Matthew Gribble,Dean A. Baker,Eric Marois,Steven Russell,Austin Burt,Nikolai Windbichler,Andrea Crisanti,Tony Nolan +13 more
TL;DR: Population modeling and cage experiments indicate that a CRISPR-Cas9 construct targeting one of these loci meets the minimum requirement for a gene drive targeting female reproduction in an insect population, which could expedite the development of gene drives to suppress mosquito populations to levels that do not support malaria transmission.
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Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi
Valentino M. Gantz,Nijole Jasinskiene,Olga Tatarenkova,Aniko Fazekas,Vanessa M. Macias,Ethan Bier,Anthony A. James +6 more
TL;DR: A highly effective autonomous Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9)-mediated gene-drive system in the Asian malaria vector Anopheles stephensi, adapted from the mutagenic chain reaction (MCR).
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Concerning RNA-guided gene drives for the alteration of wild populations
TL;DR: The potential for RNA-guided gene drives based on the CRISPR nuclease Cas9 to serve as a general method for spreading altered traits through wild populations over many generations is considered.