Journal ArticleDOI
Synergistic antitumor activity of a self-assembling camptothecin and capecitabine hybrid prodrug for improved efficacy.
TLDR
This work represents a conceptual advancement in integrating two structurally distinct drugs of different action mechanisms into a single self‐assembling hybrid prodrug to construct self‐deliverable nanomedicines for more effective combination chemotherapy.About:
This article is published in Journal of Controlled Release.The article was published on 2017-10-10. It has received 50 citations till now. The article focuses on the topics: Combination chemotherapy & Camptothecin.read more
Citations
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Journal ArticleDOI
Self-assembling prodrugs
TL;DR: This review will discuss the various types of self-assembling prodrugs in development, providing an overview of the methods used to control their structure and function and, ultimately, their perspective on their current and future potential.
Journal ArticleDOI
Tumor-Specific Drug Release and Reactive Oxygen Species Generation for Cancer Chemo/Chemodynamic Combination Therapy.
Sheng Wang,Sheng Wang,Zhantong Wang,Guocan Yu,Zijian Zhou,Orit Jacobson,Yijing Liu,Ying Ma,Fuwu Zhang,Zhi-Yi Chen,Xiaoyuan Chen +10 more
TL;DR: The potent antitumor effect of the LaCIONPs is demonstrated by both in vitro and in vivo results, and is a promising nanomedicine for tumor‐specific chemo/chemodynamic combination therapy.
Journal ArticleDOI
Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy.
Yang Li,Guihua Liu,Jinyuan Ma,Jinyan Lin,Huirong Lin,Guanghao Su,Dengyue Chen,Shefang Ye,Xiaoyuan Chen,Xuan Zhu,Zhenqing Hou +10 more
TL;DR: A novel carrier‐free theranostic system with nanoscale characteristics for near‐infrared fluorescence (NIRF) and photoacoustic (PA) dual‐modal imaging‐guided synergistic chemo‐photothermal therapy (PTT) and co‐self‐assembly of both FDA‐approved agents provides a safe and “Molecular economical” strategy in the rational design of multifunctional nano‐theranostic systems.
Journal ArticleDOI
Combinational strategy for high-performance cancer chemotherapy.
TL;DR: This review surveys the most recent advances in combination therapy including combination chemotherapy, chemotherapy plus gene therapy, chemotherapyplus phototherapy, as well as chemotherapy plus immunotherapy, which might provide new guidelines for high-performance cancer treatments.
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Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for "on-demand" drug delivery
Ying Qu,Bingyang Chu,Xiawei Wei,Minyi Lei,Danrong Hu,Ruoyu Zha,Lin Zhong,Mengyao Wang,Fangfang Wang,Zhiyong Qian +9 more
TL;DR: The prepared P(CPT‐MAA) prodrug nanogels exhibited superior antitumor activity both in vitro and in vivo without observed side effects, and may be a promise delivery system for chemotherapeutic agents.
References
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Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
Ting-Chao Chou,Paul Talalay +1 more
TL;DR: A generalized method for analyzing the effects of multiple drugs and for determining summation, synergism and antagonism has been proposed and has been used to analyze experimental data obtained from enzymatic, cellular and animal systems.
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Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
TL;DR: This brief perspective article focuses on the most common errors and pitfalls, as well as the do's and don'ts in drug combination studies, in terms of experimental design, data acquisition, data interpretation, and computerized simulation.
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5-Fluorouracil: mechanisms of action and clinical strategies
TL;DR: This work has shown that novel genes identified in DNA microarray profiling have the potential to identify novel genes that are involved in mediating resistance to 5-FU, and these genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to5-FU-based chemotherapy.
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Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.