Journal ArticleDOI
Synthesis and evaluation of antioxidant properties of novel 1,2,4-triazole-based schiff base heterocycles.
Chandrashekar Aswathanarayanappa,Chandrashekar Aswathanarayanappa,Eswarappa Bheemappa,Yadav D. Bodke,Peethambar S. Krishnegowda,Srinivas Pullela Venkata,Raghu Ningegowda +6 more
TLDR
1,2,4‐triazole‐based Schiff base heterocyclic compounds synthesized and evaluated for antioxidant properties by free‐radical scavenging, anti‐hemolytic activity, lipid peroxidation, and their protective effects against DNA oxidative damage showed promising DPPH• radical scavenging activity.Abstract:
A series of 1,2,4-triazole-based Schiff base heterocyclic compounds (5a-f and 8a-i) and phenethylamines (7a-h) were synthesized and evaluated for antioxidant properties by free-radical scavenging, anti-hemolytic activity, lipid peroxidation, and their protective effects against DNA oxidative damage. Compounds 7c, 7d, 7h, 8b, and 8i showed promising DPPH(•) radical scavenging activity with the level of inhibition between 86.8% and 94%. Compounds 8a, 8b, 8d, 8g, and 8i were effective against the oxidative hemolysis of human erythrocytes and lipid peroxidation, in a dose-dependent manner, with IC50 values in the range of 55.7-80.7 and 53.2-81.2 µg/mL, respectively. Compounds 8a and 8b were effective against oxidative damage on erythrocyte ghost membrane proteins, and 8g and 8i were able to protect against DNA oxidative damage.read more
Citations
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Journal ArticleDOI
Recent advances bioactive 1,2,4-triazole-3-thiones.
TL;DR: This review contains various pharmacological activities of 1,2,4-triazole-3-thiones in one place and it is also the milestone for the new research towards this moiety.
Journal ArticleDOI
New Thiazolyl-triazole Schiff Bases: Synthesis and Evaluation of the Anti-Candida Potential.
Anca Stana,Alexandra Enache,Dan Cristian Vodnar,Cristina Nastasă,Daniela Benedec,Ioana Ionuț,Cezar Login,Gabriel Marc,Ovidiu Oniga,Brîndușa Tiperciuc +9 more
TL;DR: The chemical synthesis of a new series of thiazolyl-triazole Schiff bases B1–B15 revealed that the newly synthesized compounds have potential anti-Candida activity and evidenced the most active derivative, B10, which can be further optimized as a lead compound.
Journal ArticleDOI
Synthesis, biological activity and molecular modeling study of novel 1,2,4-triazolo[4,3-b][1,2,4,5]tetrazines and 1,2,4-triazolo[4,3-b][1,2,4]triazines.
TL;DR: The newly prepared compound showed high antibacterial, antifungal, and anti-inflammatory activities in comparing with the commercial antibiotics Indomethacin, Nalidixic acid, Imipenem, and Nystatin.
Journal ArticleDOI
A rapid and modified approach for C-7 amination and amidation of 4-methyl-7-nonafluorobutylsulfonyloxy coumarins under microwave irradiation
M. Nibin Joy,Yadav D. Bodke,K.K. Abdul Khader,M. Syed Ali Padusha,Ayyiliyath M. Sajith,A. Muralidharan +5 more
TL;DR: In this article, a facile, efficient and reliable access for the synthesis of an array of 4-methyl-7-(alkyl/aryl/heteroaryl) amino and amido coumarins has been developed by treating 4methyl7-nonafluorobutylsulfonyloxy coumarin with various amines and pyridones in presence of a catalyst combination of Pd2(dba)3/xantphos under microwave irradiation.
Journal ArticleDOI
A Novel Thiazolyl Schiff Base: Antibacterial and Antifungal Effects and In Vitro Oxidative Stress Modulation on Human Endothelial Cells.
Cristian Cezar Login,Ioana Bâldea,Brînduşa Tiperciuc,Daniela Benedec,Dan Cristian Vodnar,Nicoleta Decea,Şoimiţa Suciu +6 more
TL;DR: Experimental findings indicate that the newly synthetized Schiff base has antibacterial activity, especially on the Gram-negative P. aeruginosa, and antifungal activity, and also showed antioxidant and anti-inflammatory activities.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
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Journal Article
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Journal ArticleDOI
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
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Journal ArticleDOI
Use of a Free Radical Method to Evaluate Antioxidant Activity
TL;DR: The antiradical properties of various antioxidants were determined using the free radical 2,2-Diphenyl-1-picrylhydrazyl (DPPH*) in its radical form as discussed by the authors.