Synthesis and in vitro antimycobacterial potential of novel hydrazones of eugenol
TLDR
It was showed that antitubercular activity of novel hydrazone derivatives of eugenol is strongly connected with the position of the substituent on aromatic aldehyde or ketones.About:
This article is published in Arabian Journal of Chemistry.The article was published on 2020-02-01 and is currently open access. It has received 26 citations till now. The article focuses on the topics: Hydrazone & Eugenol.read more
Citations
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Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M(pro))
Sraa Abu-Melha,Mastoura M. Edrees,Sayed M. Riyadh,Sayed M. Riyadh,Mohamad R. Abdelaziz,Abdo A. Elfiky,Sobhi M. Gomha,Sobhi M. Gomha +7 more
TL;DR: The possibility of these three compounds to effectively bind to SARS-CoV-2 Mpro and hence, contradict the virus lifecycle is shown.
Journal ArticleDOI
Different Schiff Bases—Structure, Importance and Classification
TL;DR: Schiff bases are a vast group of compounds characterized by the presence of a double bond linking carbon and nitrogen atoms, the versatility of which is generated in the many ways to combine a variety of alkyl or aryl substituents as mentioned in this paper .
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Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones
TL;DR: A review of the latest scientific reports regarding antibacterial, antimycobacterial, and antifungal activities of hydrazide-hydrazones published between 2017 and 2021 is presented in this paper.
Journal ArticleDOI
Synthesis and in vitro bioactivity study of new hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid
Łukasz Popiołek,Paweł Patrejko,Monika Gawrońska-Grzywacz,Anna Biernasiuk,Anna Berecka-Rycerz,Dorota Natorska-Chomicka,Iwona Piątkowska-Chmiel,Anna Gumieniczek,Jarosław Dudka,Monika Wujec +9 more
TL;DR: In this study 14 novel hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid were synthesized on the basis of condensation reaction and the introduction of chloro substituent or nitro group to the molecule proved to be most advantageous, providing high cytotoxicity and selectivity to tumor cells.
Journal ArticleDOI
Tailored Functionalization of Natural Phenols to Improve Biological Activity.
TL;DR: In this article, the functionalization of selected natural phenols is critically examined, mainly highlighting their improved bioactivity after the proper chemical transformations, and the most abundant naturally occurring naturally occurring monophenols, diphenols and lipidic phenols, phenolic acids, polyphenols and curcumin derivatives are explored.
References
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Burger's medicinal chemistry and drug discovery
Manfred E. Wolff,William Foye,Robert Southgate,Neal Frederick Osborne,Michael J. Pearson,George Burton,SmithKline Beecham +6 more
Advanced organic chemistry
TL;DR: Advanced organic chemistry, Advanced organic chemistry as mentioned in this paper, کتابخانه دیجیتالی دانشگاه علوم پزش-کی و خدمات درمان شهید بهشت
Journal ArticleDOI
Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells
TL;DR: A series of novel 3-aryl-1-(4- tert -butylbenzyl) -1 H -pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 cell growth were investigated as mentioned in this paper.
Journal ArticleDOI
Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles.
TL;DR: 1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethanone 1 was prepared and used as a precursor for the synthesis of new thiazole, arylidiene and coumarin derivatives and proved to exhibit potent antioxidative activity as reflected in the ability to inhibit lipid per-oxidation in rat brain and kidney homogenates and rate erythrocyte hemolysis.
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