Synthetic antibiofilm peptides.
Cesar de la Fuente-Nunez,Marlon H. Cardoso,Elizabete de Souza Cândido,Octavio L. Franco,Robert E. W. Hancock +4 more
TLDR
Recent developments in the new field of synthetic antibiofilm peptides are reviewed, including mechanistic insights, synergistic interactions with available antibiotics, and their potential as novel antimicrobials against persistent infections caused by biofilms are reviewed.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2016-05-01 and is currently open access. It has received 157 citations till now. The article focuses on the topics: Antimicrobial peptides.read more
Citations
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Journal ArticleDOI
Antimicrobial host defence peptides: functions and clinical potential
TL;DR: The emerging potential to therapeutically harness cationic host defence peptides to treat infectious diseases, chronic inflammatory disorders and wound healing is assessed, highlighting current preclinical studies and clinical trials.
Journal ArticleDOI
The value of antimicrobial peptides in the age of resistance
Maria Magana,Muthuirulan Pushpanathan,Ana L. Santos,Leon G. Leanse,Michael Fernandez,Anastasios Ioannidis,Marc A. Giulianotti,Yiorgos Apidianakis,Steven B. Bradfute,Andrew L. Ferguson,Artem Cherkasov,Mohamed N. Seleem,Clemencia Pinilla,Cesar de la Fuente-Nunez,Themis Lazaridis,Themis Lazaridis,Tianhong Dai,Richard A. Houghten,Robert E. W. Hancock,George P. Tegos +19 more
TL;DR: The benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens are identified, advances in the deployment of novel promising antimacterial peptides are highlighted, and the needs and priorities in designing focused development strategies taking into account the most advanced tools available are underlined.
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Antimicrobial Peptides: Mechanisms of Action and Resistance:
TL;DR: Recent advances in understanding of the diverse mechanisms of action of cationic AMPs are described and the bacterial resistance against these peptides and the recently developed peptide GL13K is used as an example.
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Reassessing the Host Defense Peptide Landscape
TL;DR: This review critically examined the role of AMPs and HDPs in infectious diseases and inflammation and explored the concept of chemical space as it applies to HDPs and hypothesize that the various functions and activities of this class of molecule exist on independent but overlapping activity landscapes.
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Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions.
Nigare Raheem,Suzana K. Straus +1 more
TL;DR: This review will examine how biological assays and biophysical methods can be utilized in the context of the specific antibacterial and antibiofilm functions of AMPs.
References
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Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
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Bacterial biofilms: from the natural environment to infectious diseases.
TL;DR: It is evident that biofilm formation is an ancient and integral component of the prokaryotic life cycle, and is a key factor for survival in diverse environments.
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
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Treatment of infections associated with surgical implants.
TL;DR: This review summarizes the diagnostic challenges and explains the approaches to managing infections that are associated with various devices, including prosthetic heart valves, vascular grafts, pacemakers and defibrillators, and joint prostheses.
Journal ArticleDOI
Designing antimicrobial peptides: form follows function
TL;DR: In this article, advanced computer assisted design strategies that address the difficult problem of relating primary sequence to peptide structure, and are delivering more potent, cost-effective, broad-spectrum peptides as potential next-generation antibiotics.
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