Synthetic Polymer Scaffolds for Stem Cell Transplantation in Retinal Tissue Engineering
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TLDR
The current literature on synthetic polymer scaffolds used for stem cell transplantation, especially retinal progenitor cells is reviewed, and the advantages and disadvantages, the role of different surface modifications on cell attachment and differentiation, and controlled drug delivery are discussed.Abstract:
Age-related macular degeneration and retinitis pigmentosa are two leading causes of irreversible blindness characterized by photoreceptor loss. Cell transplantation may be one of the most promising approaches of retinal repair. However, several problems hinder the success of retinal regeneration, including cell delivery and survival, limited cell integration and incomplete cell differentiation. Recent studies show that polymer scaffolds can address these three problems. This article reviews the current literature on synthetic polymer scaffolds used for stem cell transplantation, especially retinal progenitor cells. The advantages and disadvantages of different polymer scaffolds, the role of different surface modifications on cell attachment and differentiation, and controlled drug delivery are discussed. The development of material and surface modification techniques is vital in making cell transplantation a clinical success.read more
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Injectable preformed scaffolds with shape-memory properties
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Adnan Memic,Adnan Memic,Adnan Memic,Thibault Colombani,Loek J. Eggermont,Loek J. Eggermont,Mahboobeh Rezaeeyazdi,Joseph M Steingold,Zachary J. Rogers,Kasturi Joshi Navare,Halimatu S. Mohammed,Sidi A. Bencherif +11 more
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Human neural cell interactions with orientated electrospun nanofibers in vitro
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Scaffolds for bone tissue engineering fabricated from two different materials by the rapid prototyping technique: PCL versus PLGA.
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