Journal ArticleDOI
Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review.
Miquel Bioque,Alexandre González-Rodríguez,Clemente Garcia-Rizo,Jesús Cobo,José Antonio Monreal,Judith Usall,Virginia Soria,Javier Labad +7 more
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TLDR
Future clinical trials using probiotics, prebiotics, antibiotics, or faecal microbiota transplantation need to consider potential mechanistic pathways such as the HPA axis, the immune system, or gut-brain axis hormones involved in appetite control and energy homeostasis.Abstract:
Cognitive impairment has been consistently found to be a core feature of serious mental illnesses such as schizophrenia and major mood disorders (major depression and bipolar disorder). In recent years, a great effort has been made in elucidating the biological causes of cognitive deficits and the search for new biomarkers of cognition. Microbiome and gut-brain axis (MGB) hormones have been postulated to be potential biomarkers of cognition in serious mental illnesses. The main aim of this review was to synthesize current evidence on the association of microbiome and gut-brain hormones on cognitive processes in schizophrenia and major mood disorders and the association of MGB hormones with stress and the immune system. Our review underscores the role of the MGB axis on cognitive aspects of serious mental illnesses with the potential use of agents targeting the gut microbiota as cognitive enhancers. However, the current evidence for clinical trials focused on the MGB axis as cognitive enhancers in these clinical populations is scarce. Future clinical trials using probiotics, prebiotics, antibiotics, or faecal microbiota transplantation need to consider potential mechanistic pathways such as the HPA axis, the immune system, or gut-brain axis hormones involved in appetite control and energy homeostasis.read more
Citations
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Impact of Poly I:C induced maternal immune activation on offspring's gut microbiome diversity - Implications for schizophrenia.
TL;DR: In this article, the relevance of microbiome alterations in the polyriboinosinic-polyribocytidylic (PolyI:C) mouse model to human schizophrenia was explored.
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Therapeutic implications of SARS-CoV-2 dysregulation of the gut-brain-lung axis.
Samuel D. Johnson,Omalla A. Olwenyi,Namita Bhyravbhatla,Michellie Thurman,Kabita Pandey,Elizabeth A. Klug,Morgan Johnston,Shetty Ravi Dyavar,Arpan Acharya,Anthony T. Podany,Courtney V. Fletcher,Mahesh Mohan,Kamal Singh,Siddappa N. Byrareddy +13 more
TL;DR: In this article, the authors discuss the ways severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) potentially disrupts the gut-brain-lung axis.
Journal ArticleDOI
Role of Probiotics and Diet in the Management of Neurological Diseases and Mood States: A Review
Subramanian Thangaleela,Bhagavathi Sundaram Sivamaruthi,Periyanaina Kesika,Chaiyavat Chaiyasut +3 more
TL;DR: In this paper , a review summarizes the importance and involvement of probiotics and diet in neuroprotection and managing representative neurological disorders, injuries and mood states, and concludes that probiotics could be considered an adjunct therapy to manage metabolic and psychiatric diseases.
Journal ArticleDOI
Food, nutrition and microbiota: what about the elderly?
TL;DR: The following review presents the objective of developing a search in various sources of information on the relevance of food and nutrition for the maintenance and balance of the microbiota in older people and mentions some contributions from new research.
References
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Journal ArticleDOI
Meta-analysis of Cerebrospinal Fluid Cytokine and Tryptophan Catabolite Alterations in Psychiatric Patients: Comparisons Between Schizophrenia, Bipolar Disorder, and Depression
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Journal ArticleDOI
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Emilio Fernandez-Egea,Miguel Bernardo,Thomas Donner,Ignacio Conget,Eduard Parellada,Azucena Justicia,Enric Esmatjes,Clemente Garcia-Rizo,Brian Kirkpatrick +8 more
TL;DR: Individuals with non-affective psychosis appear to have an increased prevalence of abnormal glucose tolerance prior to antipsychotic treatment, as well as abnormalities in a related inflammatory molecule that may contribute to the metabolic side-effects of antipsychotics medications.
Journal ArticleDOI
Altered colonic function and microbiota profile in a mouse model of chronic depression
Amber J. Park,Josh Collins,Patricia Blennerhassett,Jean-Eric Ghia,Elena F. Verdu,Premysl Bercik,Stephen M. Collins +6 more
TL;DR: Whether the induction of chronic depression results in changes in the colonic function and in its microbial community, and to explore underlying mechanisms is determined.
Journal ArticleDOI
Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response
Emanuel Schwarz,Johanna Maukonen,Tiina Hyytiainen,Tuula Kieseppä,Matej Orešič,Sarven Sabunciyan,Outi Mantere,Maria Saarela,Robert H. Yolken,Jaana Suvisaari +9 more
TL;DR: The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.
Journal ArticleDOI
Adipokines: a link between obesity and dementia?
Amanda J. Kiliaan,Ilse A.C. Arnoldussen,Deborah Gustafson,Deborah Gustafson,Deborah Gustafson +4 more
TL;DR: Being overweight or obese, as measured with body-mass index or central adiposity (waist circumference), and the trajectory of body- mass index over the life course have been associated with brain atrophy, white matter changes, disturbances of blood-brain barrier integrity, and risk of all-cause late-onset dementia and Alzheimer's disease.
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