Journal ArticleDOI
Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review.
Miquel Bioque,Alexandre González-Rodríguez,Clemente Garcia-Rizo,Jesús Cobo,José Antonio Monreal,Judith Usall,Virginia Soria,Javier Labad +7 more
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TLDR
Future clinical trials using probiotics, prebiotics, antibiotics, or faecal microbiota transplantation need to consider potential mechanistic pathways such as the HPA axis, the immune system, or gut-brain axis hormones involved in appetite control and energy homeostasis.Abstract:
Cognitive impairment has been consistently found to be a core feature of serious mental illnesses such as schizophrenia and major mood disorders (major depression and bipolar disorder). In recent years, a great effort has been made in elucidating the biological causes of cognitive deficits and the search for new biomarkers of cognition. Microbiome and gut-brain axis (MGB) hormones have been postulated to be potential biomarkers of cognition in serious mental illnesses. The main aim of this review was to synthesize current evidence on the association of microbiome and gut-brain hormones on cognitive processes in schizophrenia and major mood disorders and the association of MGB hormones with stress and the immune system. Our review underscores the role of the MGB axis on cognitive aspects of serious mental illnesses with the potential use of agents targeting the gut microbiota as cognitive enhancers. However, the current evidence for clinical trials focused on the MGB axis as cognitive enhancers in these clinical populations is scarce. Future clinical trials using probiotics, prebiotics, antibiotics, or faecal microbiota transplantation need to consider potential mechanistic pathways such as the HPA axis, the immune system, or gut-brain axis hormones involved in appetite control and energy homeostasis.read more
Citations
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Journal ArticleDOI
Impact of Poly I:C induced maternal immune activation on offspring's gut microbiome diversity - Implications for schizophrenia.
TL;DR: In this article, the relevance of microbiome alterations in the polyriboinosinic-polyribocytidylic (PolyI:C) mouse model to human schizophrenia was explored.
Journal ArticleDOI
Therapeutic implications of SARS-CoV-2 dysregulation of the gut-brain-lung axis.
Samuel D. Johnson,Omalla A. Olwenyi,Namita Bhyravbhatla,Michellie Thurman,Kabita Pandey,Elizabeth A. Klug,Morgan Johnston,Shetty Ravi Dyavar,Arpan Acharya,Anthony T. Podany,Courtney V. Fletcher,Mahesh Mohan,Kamal Singh,Siddappa N. Byrareddy +13 more
TL;DR: In this article, the authors discuss the ways severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) potentially disrupts the gut-brain-lung axis.
Journal ArticleDOI
Role of Probiotics and Diet in the Management of Neurological Diseases and Mood States: A Review
Subramanian Thangaleela,Bhagavathi Sundaram Sivamaruthi,Periyanaina Kesika,Chaiyavat Chaiyasut +3 more
TL;DR: In this paper , a review summarizes the importance and involvement of probiotics and diet in neuroprotection and managing representative neurological disorders, injuries and mood states, and concludes that probiotics could be considered an adjunct therapy to manage metabolic and psychiatric diseases.
Journal ArticleDOI
Food, nutrition and microbiota: what about the elderly?
TL;DR: The following review presents the objective of developing a search in various sources of information on the relevance of food and nutrition for the maintenance and balance of the microbiota in older people and mentions some contributions from new research.
References
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Journal ArticleDOI
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Geraint B. Rogers,Damien J. Keating,Richard L. Young,Ma-Li Wong,Julio Licinio,Steven Lodewyk Wesselingh +5 more
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Journal ArticleDOI
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Social Cognition as a Mediator Variable Between Neurocognition and Functional Outcome in Schizophrenia: Empirical Review and New Results by Structural Equation Modeling
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