Journal ArticleDOI
Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review.
Miquel Bioque,Alexandre González-Rodríguez,Clemente Garcia-Rizo,Jesús Cobo,José Antonio Monreal,Judith Usall,Virginia Soria,Javier Labad +7 more
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TLDR
Future clinical trials using probiotics, prebiotics, antibiotics, or faecal microbiota transplantation need to consider potential mechanistic pathways such as the HPA axis, the immune system, or gut-brain axis hormones involved in appetite control and energy homeostasis.Abstract:
Cognitive impairment has been consistently found to be a core feature of serious mental illnesses such as schizophrenia and major mood disorders (major depression and bipolar disorder). In recent years, a great effort has been made in elucidating the biological causes of cognitive deficits and the search for new biomarkers of cognition. Microbiome and gut-brain axis (MGB) hormones have been postulated to be potential biomarkers of cognition in serious mental illnesses. The main aim of this review was to synthesize current evidence on the association of microbiome and gut-brain hormones on cognitive processes in schizophrenia and major mood disorders and the association of MGB hormones with stress and the immune system. Our review underscores the role of the MGB axis on cognitive aspects of serious mental illnesses with the potential use of agents targeting the gut microbiota as cognitive enhancers. However, the current evidence for clinical trials focused on the MGB axis as cognitive enhancers in these clinical populations is scarce. Future clinical trials using probiotics, prebiotics, antibiotics, or faecal microbiota transplantation need to consider potential mechanistic pathways such as the HPA axis, the immune system, or gut-brain axis hormones involved in appetite control and energy homeostasis.read more
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Impact of Poly I:C induced maternal immune activation on offspring's gut microbiome diversity - Implications for schizophrenia.
TL;DR: In this article, the relevance of microbiome alterations in the polyriboinosinic-polyribocytidylic (PolyI:C) mouse model to human schizophrenia was explored.
Journal ArticleDOI
Therapeutic implications of SARS-CoV-2 dysregulation of the gut-brain-lung axis.
Samuel D. Johnson,Omalla A. Olwenyi,Namita Bhyravbhatla,Michellie Thurman,Kabita Pandey,Elizabeth A. Klug,Morgan Johnston,Shetty Ravi Dyavar,Arpan Acharya,Anthony T. Podany,Courtney V. Fletcher,Mahesh Mohan,Kamal Singh,Siddappa N. Byrareddy +13 more
TL;DR: In this article, the authors discuss the ways severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) potentially disrupts the gut-brain-lung axis.
Journal ArticleDOI
Role of Probiotics and Diet in the Management of Neurological Diseases and Mood States: A Review
Subramanian Thangaleela,Bhagavathi Sundaram Sivamaruthi,Periyanaina Kesika,Chaiyavat Chaiyasut +3 more
TL;DR: In this paper , a review summarizes the importance and involvement of probiotics and diet in neuroprotection and managing representative neurological disorders, injuries and mood states, and concludes that probiotics could be considered an adjunct therapy to manage metabolic and psychiatric diseases.
Journal ArticleDOI
Food, nutrition and microbiota: what about the elderly?
TL;DR: The following review presents the objective of developing a search in various sources of information on the relevance of food and nutrition for the maintenance and balance of the microbiota in older people and mentions some contributions from new research.
References
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Journal ArticleDOI
The MATRICS Consensus Cognitive Battery, Part 1: Test Selection, Reliability, and Validity
Keith H. Nuechterlein,Michael F. Green,Robert S. Kern,Lyle E. Baade,M Deanna,Jonathan D. Cohen,Susan M. Essock,Wayne S. Fenton,Frederick J. Frese,James M. Gold,Terry E. Goldberg,Robert K. Heaton,Richard S.E. Keefe,Helena C. Kraemer,Raquelle I. Mesholam-Gately,Larry J. Seidman,Ellen Stover,Daniel R. Weinberger,Alexander S. Young,Steven Zalcman,Stephen R. Marder +20 more
TL;DR: The MATRICS Consensus Cognitive Battery is expected to be the standard tool for assessing cognitive change in clinical trials of cognition-enhancing drugs for schizophrenia and may also aid evaluation of cognitive remediation strategies.
Journal ArticleDOI
The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
Gut-brain axis: how the microbiome influences anxiety and depression
TL;DR: Recent findings showing that microbiota are important in normal healthy brain function are reviewed, and ongoing and future animal and clinical studies aimed at understanding the microbiota-gut-brain axis may provide novel approaches for prevention and treatment of mental illness.
Journal ArticleDOI
The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis.
Anne-Kathrin Fett,Wolfgang Viechtbauer,Maria de Gracia Dominguez,David L. Penn,Jim van Os,Lydia Krabbendam +5 more
TL;DR: Overall, social cognition was more strongly associated with community functioning than neurocognition, with the strongest associations being between theory of mind and functional outcomes.
Journal ArticleDOI
Altered fecal microbiota composition in patients with major depressive disorder
Hai-yin Jiang,Zongxin Ling,Yong-Hua Zhang,Hongjin Mao,Zhanping Ma,Yan Yin,Weihong Wang,W.H. Wilson Tang,Zhonglin Tan,Jianfei Shi,Lanjuan Li,Bing Ruan +11 more
TL;DR: Fecal samples from 46 patients with depression are analyzed to enable a better understanding of changes in the fecal microbiota composition in such patients, showing either a predominance of some potentially harmful bacterial groups or a reduction in beneficial bacterial genera.
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