The role of microbiota in the pathogenesis of schizophrenia and major depressive disorder and the possibility of targeting microbiota as a treatment option.
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TLDR
Despite the accumulated knowledge in this field, more studies are warranted and required to further the understanding of the brain-gut axis and the possibility of targeting microbiota as a treatment option for schizophrenia and major depressive disorder.Abstract:
The importance of interactions between the brain and the gastrointestinal tract has been increasingly recognized in recent years. It has been proposed that dysregulation and abnormalities in the brain-gut axis contribute to the etiology of a variety of central nervous system disorders. Particularly, dysbiosis, or impaired microbiota, has been implicated in multiple neurological and psychological disorders. The present paper reviews current evidence and theories concerning the possible mechanisms by which microbiota dysfunction contributes to the pathogenesis of schizophrenia and major depressive disorder. Clinical trials that investigated the possibility of treating both illnesses by correcting and rebalancing microbiota with probiotics are also reviewed. Overall, despite the accumulated knowledge in this field, more studies are warranted and required to further our understanding of the brain-gut axis and the possibility of targeting microbiota as a treatment option for schizophrenia and major depressive disorder.read more
Citations
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The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice
Peng Zheng,Benhua Zeng,Meiling Liu,Jianjun Chen,Junxi Pan,Yu Han,Yiyun Liu,Ke Cheng,Chanjuan Zhou,Haiyang Wang,Xinyu Zhou,Siwen Gui,Seth W. Perry,Ma-Li Wong,Julio Licinio,Hong Wei,Peng Xie +16 more
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Faecal Short Chain Fatty Acids Profile is Changed in Polish Depressive Women
Karolina Skonieczna-Żydecka,Elżbieta Grochans,Dominika Maciejewska,Małgorzata Szkup,Daria Schneider-Matyka,Anna Jurczak,Igor Łoniewski,Mariusz Kaczmarczyk,Wojciech Marlicz,Maja Czerwińska-Rogowska,Justyna Pełka-Wysiecka,Karolina Dec,Ewa Stachowska +12 more
TL;DR: It is concluded that SCFAs may potentially contribute to depression phenotype, however, due to the small size of groups suffering from moderately heavy and severe depression, the conclusion should be treated with caution.
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Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry.
TL;DR: Microbiome-based therapies such as probiotics could be cautiously recommended for depression to enhance beneficial bacteria in the gut and to improve mood through the gut-brain axis.
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Antipsychotics, Metabolic Adverse Effects, and Cognitive Function in Schizophrenia.
Nicole E. MacKenzie,Chantel Kowalchuk,Chantel Kowalchuk,Sri Mahavir Agarwal,Sri Mahavir Agarwal,Kenya A. Costa-Dookhan,Kenya A. Costa-Dookhan,Fernando Caravaggio,Fernando Caravaggio,Philip Gerretsen,Philip Gerretsen,Araba Chintoh,Araba Chintoh,Gary Remington,Gary Remington,Valerie H. Taylor,Daniel J. Mueller,Daniel J. Mueller,Ariel Graff-Guerrero,Ariel Graff-Guerrero,Margaret Hahn,Margaret Hahn +21 more
TL;DR: It is concluded that the available literature examining the inter-section of antipsychotics, cognition, and metabolic effects in schizophrenia is sparse, but a relationship between metabolic comorbidity and worse cognitive function in patients with schizophrenia is suggested.
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Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: A randomized controlled trial
Faith Dickerson,Maria Adamos,Emily Katsafanas,Sunil Khushalani,Andrea Origoni,Christina L.G. Savage,Lucy A. B. Schweinfurth,Cassie Stallings,Kevin Sweeney,Joshana Goga,Robert H. Yolken +10 more
TL;DR: The trial examined whether the administration of probiotic organisms prevents psychiatric rehospitalizations in patients recently discharged following hospitalization for mania.
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