Journal ArticleDOI
Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review.
Miquel Bioque,Alexandre González-Rodríguez,Clemente Garcia-Rizo,Jesús Cobo,José Antonio Monreal,Judith Usall,Virginia Soria,Javier Labad +7 more
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TLDR
Future clinical trials using probiotics, prebiotics, antibiotics, or faecal microbiota transplantation need to consider potential mechanistic pathways such as the HPA axis, the immune system, or gut-brain axis hormones involved in appetite control and energy homeostasis.Abstract:
Cognitive impairment has been consistently found to be a core feature of serious mental illnesses such as schizophrenia and major mood disorders (major depression and bipolar disorder). In recent years, a great effort has been made in elucidating the biological causes of cognitive deficits and the search for new biomarkers of cognition. Microbiome and gut-brain axis (MGB) hormones have been postulated to be potential biomarkers of cognition in serious mental illnesses. The main aim of this review was to synthesize current evidence on the association of microbiome and gut-brain hormones on cognitive processes in schizophrenia and major mood disorders and the association of MGB hormones with stress and the immune system. Our review underscores the role of the MGB axis on cognitive aspects of serious mental illnesses with the potential use of agents targeting the gut microbiota as cognitive enhancers. However, the current evidence for clinical trials focused on the MGB axis as cognitive enhancers in these clinical populations is scarce. Future clinical trials using probiotics, prebiotics, antibiotics, or faecal microbiota transplantation need to consider potential mechanistic pathways such as the HPA axis, the immune system, or gut-brain axis hormones involved in appetite control and energy homeostasis.read more
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Journal ArticleDOI
The microbiota-gut-brain axis and its modulation in the therapy of depression: comparison of efficacy of conventional drugs and traditional Chinese medicine approaches.
TL;DR: In this article , the authors summarize the role of the microbiota-gut-brain axis (MGBA) in the occurrence and development of depression, especially the important role of MGBA in the mechanism of action of antidepressants.
Book ChapterDOI
Therapeutic Implications of the Microbial Hypothesis of Mental Illness.
Jonathan Savitz,Robert H. Yolken +1 more
TL;DR: There is increasingly compelling evidence that microorganisms may play an etiological role in the emergence of mental illness in a subset of the population as mentioned in this paper , and the potential therapeutic effects of probiotics in the context of schizophrenia, bipolar disorder, and major depressive disorder.
Journal ArticleDOI
Effect of Tanshinone IIA on Gut Microbiome in Diabetes-Induced Cognitive Impairment
Yanfang Zheng,Xian-Ying Zhou,Chen-xi Wang,Jialin Zhang,Dennis Chang,Wenjing Liu,MingXing Zhu,Shuting Zhuang,Hong-ning Shi,Xiaoping Wang,Yong Chen,Zaixing Cheng,Yan-hua Lin,Lihong Nan,Yibin Sun,Li Min,Jin Liu,Jianyu Chen,Jie Zhang,Mingqing Huang +19 more
TL;DR: This study confirmed that TAN reduced the FBG level and improved the cognitive and memory function against HFD- and STZ-induced diabetes and supported the use of TAN as a promising therapeutic agent for DCI, in which the underlying mechanism may be associated with gut microbiome regulation.
Journal ArticleDOI
Prevalence, profile and associations of cognitive impairment in Ugandan first-episode psychosis patients
TL;DR: In this article , the authors used the MATRICS consensus cognitive battery (MCCB) to determine the prevalence, profile and associations of various exposures with cognitive impairment in Ugandan first-episode psychosis patients.
Journal ArticleDOI
Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence
Wenyu Dai,Jieyu Liu,Yan Qiu,Ziwei Teng,Sujuan Li,Hui Yuan,Jing Huang,Hui Xiang,Hui Tang,Bo-min Wang,Jindong Chen,Haishan Wu +11 more
TL;DR: This review sought to explore the potential mechanisms of how gut microbial dysbiosis affects cognitive function in bipolar disorder and identify potential microbiota-centered treatment for BD-related cognitive impairment.
References
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Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
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Journal ArticleDOI
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Journal ArticleDOI
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
John F. Cryan,Timothy G. Dinan +1 more
TL;DR: The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
Journal ArticleDOI
Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
Jessica M. Yano,Kristie B. Yu,Gregory P. Donaldson,Gauri G. Shastri,Phoebe Ann,Liang Ma,Cathryn R. Nagler,Rustem F. Ismagilov,Sarkis K. Mazmanian,Elaine Y. Hsiao +9 more
TL;DR: It is demonstrated that Indigenous spore-forming bacteria from the mouse and human microbiota promote 5-HT biosynthesis from colonic enterochromaffin cells (ECs), which supply 5- HT to the mucosa, lumen, and circulating platelets and elevating luminal concentrations of particular microbial metabolites increases colonic and blood5-HT in germ-free mice.
Journal ArticleDOI
Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice.
Nobuyuki Sudo,Yoichi Chida,Yuji Aiba,Junko Sonoda,Naomi Oyama,Xiao Nian Yu,Chiharu Kubo,Yasuhiro Koga +7 more
TL;DR: Exposure to microbes at an early developmental stage is required for the HPA system to become fully susceptible to inhibitory neural regulation, and results suggest that commensal microbiota can affect the postnatal development of the Hpa stress response in mice.
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