TDP-43 condensation properties specify its RNA-binding and regulatory repertoire
Martina Hallegger,Martina Hallegger,Anob M. Chakrabarti,Flora C.Y. Lee,Flora C.Y. Lee,Bo Lim Lee,Aram G. Amalietti,Aram G. Amalietti,Hana M. Odeh,Katie E. Copley,Jack D. Rubien,Bede Portz,Klara Kuret,Ina Huppertz,Frédérique Rau,Frédérique Rau,Rickie Patani,Rickie Patani,Nicolas L. Fawzi,James Shorter,Nicholas M. Luscombe,Nicholas M. Luscombe,Jernej Ule,Jernej Ule +23 more
TLDR
In this paper, a series of TDP-43 C-terminal domain (CTD) variants exhibited a gradient of low to high condensation propensity, as observed in vitro and by nuclear mobility and foci formation.About:
This article is published in Cell.The article was published on 2021-09-02 and is currently open access. It has received 71 citations till now. The article focuses on the topics: RNA-binding protein & RNA.read more
Citations
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TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
Pierre-Marie Lledo,Chongmin Wang +1 more
TL;DR: In this paper , the authors show that TDP-43 is a repressor of exon inclusion during RNA splicing, which is a hallmark pathological feature of the neurodegenerative diseases ALS and frontotemporal dementia.
Journal ArticleDOI
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
TL;DR: This Review provides insight into the regulation of lncRNA transcription and processing gleaned from the application of recently devised nascent transcriptomics technology, and compares and contrast different methodologies for studying nascent transcription.
Journal ArticleDOI
Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases
Jenny L. Carey,Lin Guo +1 more
TL;DR: Restoration of functional protein phase of TDP-43 and FUS could be beneficial for neuronal cells because aberrant phase transition of these proteins leads to protein aggregation and disrupts their regular cell function.
Journal ArticleDOI
Specific RNA interactions promote TDP-43 multivalent phase separation and maintain liquid properties.
Zachary R. Grese,Alliny Cs Bastos,Lohany D Mamede,Rachel L. French,Timothy M. Miller,Yuna M. Ayala +5 more
TL;DR: In this paper, RNA-driven condensation increases with the number of adjacent TDP-43-binding sites and is also mediated by multivalent interactions involving the amino and carboxy-terminal domains.
Journal ArticleDOI
Principles Governing the Phase Separation of Multidomain Proteins.
Priyesh Mohanty,Utkarsh Kapoor,Dinesh Sundaravadivelu Devarajan,Tien M. Phan,Azamat Rizuan,Jeetain Mittal +5 more
TL;DR: The general principles underlying liquid-liquid phase separation are illustrated on the basis of examples of multidomain proteins that are predominantly associated with nucleic acid binding and protein quality control and contain both folded and disordered regions.
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